Sickle cell disease: open trials in United States

• NCT05904093

  Study to Evaluate the Safety and Tolerability of Escalating Doses of Fostamatinib in Subjects With Stable Sickle Cell Disease

  Trial Treatment · Phase 1 · National Heart, Lung, and Blood Institute (NHLBI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-11-05

• NCT06665997

  Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease

  Trial Treatment · Phase 4 · University of Pennsylvania

  Emory University, Atlanta · Children's Hospital of Philadelphia, Philadelphia

  Registry updated 2026-11-05

• NCT07799571

  Buprenorphine for the Management of Pain in Children With Sickle Cell Disease

  Trial Treatment · Phase 1 · Natasha Archer

  Boston Children's Hospital, Boston

  Registry updated 2026-11-04

• NCT07224360

  Safety of Anumigilimab (CSL324) in Adults With Sickle Cell Disease (SCD)

  Trial Treatment · Phase 2 · CSL Behring

  Arthur M Blank Hospital - Children's Healthcare of Atlanta, Atlanta · Center for Cancer and Blood Disorders, Bethesda · Boston Medical Center, Boston · Ohio State University, Columbus · Southern Specialty Research, Flowood · The Foundation for Sickle Cell Disease, Hollywood · UT Physicians Comprehensive Adult Sickle Cell Center, Houston · NYC Health + Hospitals/Queens, Jamaica · UAMS Medical Center, Little Rock · University of Minnesota, Minneapolis · Columbia University Medical Center, New York · University of California Irvine, Orange · Virginia Commonwealth University, Richmond · Jacobi Medical Center, The Bronx

  Registry updated 2026-11-03

• NCT07911618

  Data Collection For Patients With Sickle Cell Disease

  Research · M.D. Anderson Cancer Center

  UT MD Anderson Cancer Center, Houston

  Registry updated 2026-11-03

• NCT06743113

  Hypoxic Red Blood Cells in Sickle Cell Anemia

  Trial Treatment · Hemanext

  Emory University School of Medicine, Atlanta · John Hopkins University School of Medicine, Baltimore · University of Illinois at Chicago, Chicago · New England Sickle Cell Institute, University of Connecticut, Farmington · University of Pittsburgh Medical Center, Pittsburgh

  Registry updated 2026-11-02

• NCT07145411

  HPC Offered for PRESERVE Expansion

  Research · Ossium Health, Inc.

  University of Alabama Birmingham, Birmingham · The Ohio State University Medical Center, Columbus · Henry Ford Health, Detroit · City of Hope, Duarte · TriStar Centennial Medical center, Nashville

  Registry updated 2026-11-02

• NCT07910396

  Focused Ultrasound Neuromodulation for Chronic Pain

  Trial Treatment · University of Minnesota

  Masonic Institute for the Developing Brain, Minneapolis

  Registry updated 2026-11-02

• NCT07656415

  A Study to Investigate the Effect of Mitapivat on Transfusion Burden in Subjects With Sickle Cell Disease (SCD)

  Trial Treatment · Phase 3 · Agios Pharmaceuticals, Inc.

  Southern Specialty Clinic, Flowood · The Cancer and Hematology Centers (CHC), Grand Rapids · University of Texas Health Science Center at Houston, Houston · Indiana Hemophilia & Thrombosis Center, Indianapolis · Icahn School of Medicine at Mount Sinai, New York

  Registry updated 2026-10-28

• NCT03685721

  Genotype -Phenotype Correlation of PKLR Variants With Pyruvate Kinase, 2,3-Diphosphglycerate and Adenosine Triphosphate Activities in Red Blood Cells of People With Sickle Cell Disease

  Research · National Heart, Lung, and Blood Institute (NHLBI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-27

• NCT06546670

  A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease

  Trial Treatment · Phase 1/2 · Novartis Pharmaceuticals

  University of Alabama Birmingham, Birmingham · Boston Childrens Hospital, Boston · Levine Cancer Insitute Carolinas Healthcare System, Charlotte · East Carolina University, Greenville · UT Health Science Center, Houston · Quotient Sciences Sea View, Miami · Icahn School Of Med At Mount Sinai, New York · Childrens Hospital of Philadelphia, Philadelphia · Lifespan, Providence

  Registry updated 2026-10-27

• NCT00047996

  Blood Collection for Research Related to Certain Diseases Involving Blood Vessels

  Research · National Heart, Lung, and Blood Institute (NHLBI)

  National Institutes of Health Clinical Center, Bethesda · INOVA Fairfax Hosptial, Fairfax

  Registry updated 2026-10-26

• NCT00542230

  Blood Sampling for Research Related to Sickle Cell Disease

  Research · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-26

• NCT04008368

  Repeat Peripheral Blood Stem Cell Transplantation for Patients With Sickle Cell Disease and Falling Donor Myeloid Chimerism Levels

  Trial Treatment · Phase 1/2 · National Heart, Lung, and Blood Institute (NHLBI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-26

• NCT04099966

  AlloSCT for Malignant and Non-malignant Hematologic Diseases Utilizing Alpha/Beta T Cell and CD19+ B Cell Depletion

  Trial Treatment · Phase 2 · Mitchell Cairo

  New York Medical College, Valhalla

  Registry updated 2026-10-23

• NCT05213572

  Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

  Research · National Heart, Lung, and Blood Institute (NHLBI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-22

• NCT07090668

  Trans-auricular Nerve Stimulation as an Innovative Approach to the Treatment of Pain in Pediatric Patients Suffering From Sickle Cell Disease

  Trial Treatment · Emory University

  Children's Hospital of Atlanta: Eagelston, Atlanta

  Registry updated 2026-10-22

• NCT00081523

  Natural History of Sickle Cell Disease

  Research · National Heart, Lung, and Blood Institute (NHLBI)

  National Institutes of Health Clinical Center, Bethesda · Suburban Hospital, Bethesda · Childrens National Health Center, Washington D.C.

  Registry updated 2026-10-21

• NCT07566494

  Escalating Doses of VAS-101 in Subjects With Stable Sickle Cell Disease

  Trial Treatment · Phase 1 · National Heart, Lung, and Blood Institute (NHLBI)

  National Institutes of Health Clinical Center, Bethesda

  Registry updated 2026-10-21

• NCT07708350

  Hematopoietic Stem Cell BCL11A Enhancer Gene Editing for Sickle Cell Disease

  Trial Treatment · Phase 1 · Daniel Bauer

  Boston Children's Hospital, Boston

  Registry updated 2026-10-21

• NCT04774536

  Transplantation of Clustered Regularly Interspaced Short Palindromic Repeats Modified Hematopoietic Progenitor Stem Cells (CRISPR_SCD001) in Patients With Severe Sickle Cell Disease

  Trial Treatment · Phase 1/2 · Mark Walters, MD

  University of California, Davis, Davis · University of California, Los Angeles, Los Angeles · UCSF Benioff Children's Hospital, Oakland

  Registry updated 2026-10-20

• NCT07674277

  Virtual Reality for SCD VOC

  Trial Treatment · University of Maryland, Baltimore

  University of Maryland Medical Center, Stoler Infusion Center, Baltimore

  Registry updated 2026-10-16

• NCT06439082

  A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

  Trial Treatment · Phase 3 · Novartis Pharmaceuticals

  Augusta University Georgia, Augusta · The Johns Hopkins University School of Medicine, Baltimore · University of Alabama, Birmingham · Uni of Illinois Hospital and HSC, Chicago · Spoknwrdclinicaltrials, Easton · Southern Specialty Research, Flowood · East Carolina University, Greenville · Texas Childrens Cancer and Hematology Center, Houston · U of TX Health Science Ct, Houston · University of Florida, Jacksonville · Norton Children's Hospital, Louisville · Ctr for Inherited Blood Disorders, Orange · Thomas Jefferson University Me, Philadelphia · WCG Sonar Clinical Research, Riverdale · Childrens Hospital at Montefiore, The Bronx · Childrens National Hospital, Washington D.C. · Wake Forest University Baptist Medical Center, Winston-Salem

  Registry updated 2026-10-15

• NCT06506461

  Gene Editing For Sickle Cell Disease

  Trial Treatment · Phase 1 · St. Jude Children's Research Hospital

  St. Jude Children's Research Hospital, Memphis

  Registry updated 2026-10-15

• NCT06975865

  The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease

  Trial Treatment · Phase 3 · Sanofi

  University of Michigan Health System - Ann Arbor- Site Number : 8400035, Ann Arbor · University of Maryland School of Medicine - Baltimore- Site Number : 8400041, Baltimore · University of Alabama at Birmingham- Site Number : 8400003, Birmingham · University of Illinois-Chicago - College of Medicine- Site Number : 8400054, Chicago · University of California San Francisco- Site Number : 8400040, Clovis · Oncology & Hematology Associates of West Broward- Site Number : 8400029, Coral Springs · Flowood · Prisma Health- Site Number : 8400051, Greenville · UT Physicians - Memorial Hermann- Site Number : 8400052, Houston · Baylor College of Medicine- Site Number : 8400055, Houston · Indiana University Health Riley Hospital for Children- Site Number : 8400056, Indianapolis · David Geffen School of Medicine at UCLA- Site Number : 8400032, Los Angeles · University of Tennessee Health Science Center- Site Number : 8400045, Memphis · Sylvester Comprehensive Cancer Center- Site Number : 8400020, Miami · Phoenix Children's Hospital- Site Number : 8400028, Phoenix · Oregon Health & Science University (OHSU)- Site Number : 8400043, Portland · VCU Massey Cancer Center: Dalton Oncology Clinic- Site Number : 8400012, Richmond · Louisiana State University Health Sciences Center - Shreveport- Site Number : 8400037, Shreveport · Richmond University Medical Center- Site Number : 8400038, Staten Island · Montefiore Medical Center - Moses Campus- Site Number : 8400057, The Bronx · MedStar Georgetown University Hospital- Site Number : 8400036, Washington D.C.

  Registry updated 2026-10-15

All Sickle cell disease trials and the map

This page is not medical advice. Talk to your doctor before contacting a trial.

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