Sickle cell disease trials in United States

In United States 133 Also abroad 204

133 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

Phase 3Taking people
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
Where
Ann Arbor, Baltimore, Birmingham, Chicago, Clovis, Coral Springs, Flowood, Greenville, Houston, Indianapolis, Los Angeles, Memphis, Miami, Phoenix, Portland, Richmond, Shreveport, Staten Island, The Bronx, Washington D.C.
Age
10 years to 65 years
People
192 worldwide
Run by
Sanofi
See details and how to joinNCT06975865
No phaseNot yet taking people in United States
Self-administered Acupressure in Patients With Sickle Cell Disease
Where
Cincinnati, Irvine
Age
18 years to 80 years
People
300
Run by
University of Cincinnati
See details and how to joinNCT07875777
Phase 1/2Taking people
Partial Stem Cell Transplant for Sickle Cell Disease From Matched Donors
Where
Bethesda
Age
4 years to 65 years
People
90
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT07599176
No phaseTaking people
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
Where
Ann Arbor, Atlanta, Chicago, Durham, Greenville, Hartford, Los Angeles, Mobile, Newark, New York, Pittsburgh, Richmond, Rochester
Age
16 years to 39 years
People
390
Run by
University of Pittsburgh
See details and how to joinNCT06374238
Phase 2Taking people
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
Where
Atlanta, Baltimore, Chicago, Cincinnati, Columbus, Detroit, Fort Myers, Greenville, Hollywood, Louisville, New York, Oakland, Orange, Pittsburgh, Richmond, St Louis, The Bronx, Washington D.C.
Age
12 years and over
People
70 worldwide
Run by
CSL Behring
See details and how to joinNCT06699849 · EU 2024-513440-29-00
Phase 1Taking people
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
Where
Atlanta, Augusta, Birmingham, Chicago, Cincinnati, Durham, Greenville, Indianapolis, New York, Pittsburgh, San Francisco
Age
18 years and over
People
24
Run by
Disc Medicine, Inc
See details and how to joinNCT07187973
No phaseTaking people
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Where
Bethesda
Age
18 years to 70 years
People
300
Run by
National Institute of Allergy and Infectious Diseases (NIAID)
See details and how to joinNCT03937817
No phaseTaking people
Exercise in Child Health
Where
Irvine
Age
10 years to 17 years
People
240
Run by
University of California, Irvine
See details and how to joinNCT05359991
Phase 1Taking people
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
Where
Chicago
Age
18 years and over
People
20
Run by
EpiDestiny, Inc.
See details and how to joinNCT04055818
Early phase 1Taking people
Determination of Red Cell Survival in Sickle Cell Disease and Other Hemoglobinopathies Using Biotin Labeling
Where
Bethesda
Age
18 years to 100 years
People
100
Run by
National Heart, Lung, and Blood Institute (NHLBI)
See details and how to joinNCT06313398
No phaseTaking people
Dietary Intake and Dietary Behaviors in Adults With Sickle Cell Disease
Where
Bethesda
Age
18 years to 120 years
People
80
Run by
National Institutes of Health Clinical Center (CC)
See details and how to joinNCT05170412
Phase 3Taking people
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
Where
Atlanta, Augusta, Birmingham, Boston, Brooklyn, Charleston, Charlotte, Chicago, Cincinnati, Durham, Farmington, Greenville, Hollywood, Houston, Los Angeles, Memphis, Miami, Milwaukee, New Orleans, New York, North Canton, Oakland, Orange, Phoenix, Richmond, St Louis, Tacoma, The Bronx, Washington D.C., Winston-Salem
Age
2 years and over
People
480 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06609226 · EU 2024-510805-27-00
Phase 3Taking people
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
Where
Atlanta, Aurora, Birmingham, Boston, Brooklyn, Chicago, Cleveland, Columbus, Detroit, Durham, Fairfax, Greenville, Hollywood, Houston, Las Vegas, Little Rock, Los Angeles, Madera, Memphis, Minneapolis, Mobile, Mount Kisco, Newark, New Orleans, Norfolk, Oklahoma City, Omaha, Orange, Palo Alto, Philadelphia, Phoenix, Queens, Richmond, St Louis, Tacoma, The Bronx, Torrance, Washington D.C., Wilmington, Winston-Salem
Age
12 years and over
People
510 worldwide
Run by
Novo Nordisk A/S
See details and how to joinNCT06612268 · EU 2023-509175-16-00
Phase 2Taking people
Tocilizumab for Acute Chest Syndrome
Where
Chicago
Age
12 years and over
People
200
Run by
University of Chicago
See details and how to joinNCT05640271
No phaseTaking people
Sickle Cell Disease Biofluid Chip Technology (SCD BioChip)
Where
Cleveland
Age
12 years and over
People
100
Run by
University Hospitals Cleveland Medical Center
See details and how to joinNCT02824471
No phaseTaking people
Study to Understand the Genetic Risk of Developing an Immune Response After Blood Transfusions Among Individuals With Sickle Cell Disease
Where
Bethesda
Age
2 years to 99 years
People
50
Run by
National Human Genome Research Institute (NHGRI)
See details and how to joinNCT06944067
No phaseTaking people
Assessing Molecular Mechanisms and Effects of Music Therapy in Youth With Sickle Cell Disease Using Single-cell RNA-sequencing
Where
Atlanta
Age
8 years to 18 years
People
25
Run by
Emory University
See details and how to joinNCT07562451
Phase 2Taking people
Early Screening and Treatment of Heart Complication in Sickle Cell Disease
Where
Fairfax, Falls Church
Age
18 years and over
People
100
Run by
Inova Health Care Services
See details and how to joinNCT07023666
Phase 1Taking people
Methylphenidate to Address Attention and Executive Deficits Among Children With Sickle Cell Disease
Where
Memphis
Age
8 years to 17 years
People
72
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT07226219
Phase 1Taking people
SCD Stem Cell Mobilization and Apheresis Using Motixafortide
Where
Bethesda, Birmingham, Memphis
Age
18 years and over
People
20
Run by
St. Jude Children's Research Hospital
See details and how to joinNCT06442761
Phase 2Taking people
Sub-dissociative Dose Ketamine in Treatment of Vaso-occlusive Pain Event in Children and Young Adults
Where
Torrance
Age
5 years to 20 years
People
120
Run by
Mohsen Saidinejad
See details and how to joinNCT07369024
No phaseTaking people
Cerebrovascular Reactivity Measurements With High-Density Diffuse Optical Tomography
Where
St Louis
Age
6 years to 70 years
People
120
Run by
Washington University School of Medicine
See details and how to joinNCT07776444
Phase 2/3Taking people
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
Where
Atlanta, Baton Rouge, Chapel Hill, Chicago, Clinton, Detroit, Dunwoody, Durham, Fairfax, Flowood, Greenville, Greer, Hartford, Houston, Kansas City, Madison, Mobile, Morrisville, New Brunswick, New Haven, New Orleans, New York, Plantation, Riverdale, Simpsonville, Southfield, The Bronx, Travelers Rest, West Palm Beach
Age
12 years to 64 years
People
389 worldwide
Run by
Pfizer
See details and how to joinNCT05431088 · EU 2023-508766-14-00
Phase 1/2Taking people
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
Where
Atlanta, Baltimore, Birmingham, Boston, Chicago, Cleveland, Fairfax, Greenville, La Jolla, Lenexa, New Haven, Oakland, Philadelphia, Pittsburgh, Richmond, St Louis
Age
18 years and over
People
224 worldwide
Run by
Bristol-Myers Squibb
See details and how to joinNCT06481306 · EU 2023-510283-12-00
No phaseTaking people
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
Where
Akron, Albuquerque, Atlanta, Austin, Baltimore, Boston, Buffalo, Chapel Hill, Charlotte, Chicago, Cincinnati, Cleveland, Columbus, Dallas, Dayton, Detroit, Gainesville, Green Bay, Greenville, Hartford, Houston, Hyde Park, Indianapolis, Iowa City, Kansas City, Las Vegas, Little Rock, Los Angeles, Memphis, Miami, Milwaukee, Nashville, Newark, New Haven, New Orleans, New York, Norfolk, Oakland, Orlando, Peoria, Philadelphia, Phoenix, Pittsburgh, Providence, Reno, Rochester, Sacramento, San Antonio, San Bernardino, San Diego, San Francisco, Savannah, Scarborough, Seattle, St Louis, St. Petersburg, Tampa, The Bronx, Toledo, Washington D.C., Wilmington, Winston-Salem
People
3,000
Run by
American Thrombosis and Hemostasis Network
See details and how to joinNCT04398628