Triple-negative breast cancer trials in South Africa

4 trials · From ClinicalTrials.gov, checked 11 November 2026. Ask the study team whether a trial fits you.

• Phase 3Taking people
  A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

  Where

  Cape Town, Johannesburg, Port Elizabeth, Pretoria, Sandton

  Age

  18 years and over

  People

  2,400 worldwide

  Run by

  Merck Sharp & Dohme LLC

  See details and how to joinNCT06966700 · EU 2024-520190-12-00
• Early phase 1Taking people
  Imaging Study in Metastatic UC, HR+ and HER2- Breast Cancer, TNBC, and NSCLC

  Where

  Johannesburg, Pretoria

  Age

  18 years and over

  People

  40 worldwide

  Run by

  RayzeBio, Inc.

  See details and how to joinNCT07671092
• Phase 3Taking people
  A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)

  Where

  Cape Town, Johannesburg, Paarl, Pretoria

  Age

  18 years and over

  People

  625 worldwide

  Run by

  AstraZeneca

  See details and how to joinNCT06103864
• Phase 2/3Taking people
  A Study of Izalontamab Brengitecan Versus Chemotherapy in Participants With Previously Untreated, Locally Advanced, Recurrent Inoperable, or Metastatic Triple-negative Breast Cancer Ineligible for Anti-PD(L)1 Drugs (IZABRIGHT-Breast01)

  Where

  East London, Johannesburg, Panorama, Pretoria, Soweto

  Age

  18 years and over

  People

  600 worldwide

  Run by

  Bristol-Myers Squibb

  See details and how to joinNCT06926868 · EU 2024-519871-24-00