Tuberculosis: open trials in South Africa

34 open trials have a site in South Africa. Registry data; only the trial team decides who can take part.

NCT05947890
Evaluating the Safety and Immunogenicity of MTBVAC
Trial Treatment · Phase 2 · HIV Vaccine Trials Network
Cape Town - Groote Schuur, Cape Town · Cape Town - Khayelitsha, Cape Town · Cape Town - UCTLI, Cape Town · Cape Town - Emavundleni, Cape Town · Durban - Chatsworth, Chatsworth · Durban - Wentworth, Durban · Durban - Botha's Hill CRS, Durban · Durban eThekwini, Durban · Durban - Isipingo, Isipingo · Soweto - Gauteng, Johannesburg · Klerksdorp, Klerksdorp · Ladysmith, Ladysmith · Rustenburg CRS, Rustenburg · Soshanguve, Soshanguve · Johannesburg - CHRU, Westdene · Worcester - SATVI, Worcester
Registry updated 2026-10-30
NCT05671718
Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB Treatment
Trial Treatment · Johns Hopkins University
King Dinuzulu TB Hospital, East London · Nkquebela TB Hospital, East London · Doris Goodwin Hospital, Pietermaritzburg · Jose Pearson Hospital, Port Elizabeth · Murchison Hospital, Port Shepstone
Registry updated 2026-10-26
NCT07163143
Optimal Treatment Duration for Radiographically Apparent, Bacteriologically Unconfirmed TB, Identified Through Active Case Finding (RADIO-TB Trial)
Trial Treatment · Phase 3 · University College, London
Clinical HIV Research Unit, Wits Health Consortium, Johannesburg · The Aurum Institute, Johannesburg
Registry updated 2026-10-26
NCT07209761
A Study of Quabodepistat-containing Regimens for the Treatment of Drug-resistant Pulmonary Tuberculosis
Trial Treatment · Phase 3 · Otsuka Pharmaceutical Development & Commercialization, Inc.
Brooklyn Chest Hospital, Belville · UCT - Lung Infection and Immunity Unit, Cape Town · UCT Lung Institute, Cape Town · Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban · Synergy Biomed Research Institute, East London · Clinical HIV Research Unit (CHRU), Helen Joseph Hospital, Johannesburg · The Aurum Institute - Tembisa Hospital Clinical Research Centre, Johannesburg · Sizwe Clinical Research Site (CHRU) - Sizwe Tropical Disease Hospital,, Johannesburg · Klerksdorp/Tshepong Hospital Complex, Tshepong Hospital, MDR Unit, Klerksdorp · Isango Lethemba TB Res Unit (CHRU) - Jose Pearson TB Hospital, Port Elizabeth · Setshaba Research Center, Pretoria · The Aurum Institute - Rustenburg, Rustenburg · Perinatal HIV Research Unit (PHRU) - Chris Hani Baragwanath Academic Hospital, Soweto
Registry updated 2026-10-26
NCT07883226
A Phase 1 Multiple Dose Trial in Healthy Adult Participants to Evaluate the Safety, Tolerability, Drug-Drug Interactions, and Pharmacokinetics of TBD11
Trial Treatment · Phase 1 · Gates Medical Research Institute
Farmovs Pty Ltd, Bloemfontein
Registry updated 2026-10-22
NCT05989802
Rapid Research in Diagnostics Development for TB Network (R2D2 Kids) and Assessing Diagnostics At POC for TB in Children (ADAPT for Kids)
Trial Treatment · University of California, San Francisco
Dora Nginza Hospital, Cape Town
Registry updated 2026-10-15
NCT06114628
Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB
Trial Treatment · Phase 2 · University College, London
TASK Brooklyn, Cape Town · University of Cape Town Lung Institute, Cape Town · Task Eden, George
Registry updated 2026-10-15
NCT06314386
Systems Analysis and Improvement Approach to Prevent TB
Trial Treatment · Boston College
Addo Clinic, Addo · Lukhanyiso Clinic, Addo · Kwa-Nonqubela Clinic, Alexandria · Marselle Clinic, Boesmansriviermond · Masakhane Clinic, Hankey · Humansdorp Clinic, Humansdorp · Pellsrus Clinic, Jeffrey's Bay · Twee Riviere Clinic, Joubertina · Joubertina CHC, Joubertina · Louterwater Clinic, Joubertina · Kareedouw Clinic, Kareedouw · Kenton On Sea Clinic, Kenton on Sea · Kirkwood Clinic, Kirkwood · Moses Mabida Clinic, Kirkwood · Imizamo Yetho Clinic, Patensie · Nkwenkwezi Clinic, Port Alfred
Registry updated 2026-10-01
NCT07773610
Study of Combinations of Novel Promising Drugs for Pulmonary Tuberculosis
Trial Treatment · Phase 2 · TASK Applied Science
TASK Brooklyn, Cape Town
Registry updated 2026-09-25
NCT05842161
South Africa Smoking Cessation and Engagement in HIV/TB Care Care
Trial Treatment · Massachusetts General Hospital
University of Cape Town, Rondebosch
Registry updated 2026-09-09
NCT07118059
Effects of Adjunct Omega-3 Long Chain Polyunsaturated Fatty Acids in Pulmonary Tuberculosis Patient: an Early Bactericidal Activity and Inflammatory Trial
Trial Treatment · Phase 2 · North-West University, South Africa
Perinatal HIV research Unit (Matlosana), Klerksdorp
Registry updated 2026-09-09
NCT07672405
Sorfequiline-based Regimens in Adults With Newly Diagnosed Drug-sensitive Pulmonary TB
Trial Treatment · Phase 2 · Global Alliance for TB Drug Development
Madiberg Centre for Research, Brits · University of Capetown Lung Institute, Cape Town · Synergy Biomed Research Institute, East London · Perinatal HIV Research Unit, Tshepong Hospital, Klerksdorp · Isango Lethemba TB Research Unit, Port Elizabeth · The Aurum Institute - Rustenburg, Rustenburg · Setshaba Research Centre, Soshanguve · Durban International Clinical Research Site, Wentworth
Registry updated 2026-08-19
NCT07525427
Bactericidal Activity of TBD09 in Combination With Other Drugs in Pulmonary Tuberculosis
Trial Treatment · Phase 2 · Gates Medical Research Institute
CHRU @ Isango Lethemba, Bethelsdorp · Madibeng Centre for Research, Brits · ONE MRI, Cape Town · BioMedical Research Institute - Stellenbosch University @ Tygerberg Hospital, Cape Town · UCT Lung Institute (Pty) Ltd (Centre for TB Research Innovation), Cape Town · Desmond Tutu Health Foundation, Cape Town · TASK Applied Science - Brookylyn Chest Hospital, Cape Town · Enhancing Care Foundation at Wentworth Hospital, Durban · Synergy Biomedical Research Institute (SBRI), East London · TASK Applied Science - Eden, George · Clinical Research and HIV Research Unit (CHRU) @ Helen Joseph Hospital, Johannesburg · Setshaba Research Center, Pretoria · The Aurum Institute Tembisa, Tembisa
Registry updated 2026-07-30
NCT06253715
Shortened Regimen for Drug-susceptible TB in Children
Trial Treatment · Phase 3 · Johns Hopkins University
Africa Health Research Institute (AHRI), Durban
Registry updated 2026-07-24
NCT06221488
Testing Health Workers At Risk to Advance Our Understanding of TB Infection
Research · Beth Israel Deaconess Medical Center
Stellenbosch University, Cape Town
Registry updated 2026-07-08
NCT07675954
A 6-Month MDR-END Plus Regimen for Rifampicin-Resistant Tuberculosis
Trial Treatment · Phase 3 · Seoul National University Hospital
Desmond Tutu TB Centre, Brooklyn Chest Hospital Trial Unit, Cape Town · Perinatal HIV Research Unit, PHRU-Matlosana, Tshepong Hospital, Klerksdorp
Registry updated 2026-06-30
NCT04145258
Intensified Tuberculosis Treatment to Reduce the Mortality of Patients With Tuberculous Meningitis
Trial Treatment · Phase 3 · ANRS, Emerging Infectious Diseases
Kayelitsha District Hospital, Cape Town · New Somerset Hospital, Cape Town · Mitchells Plain Hospital, Cape Town · Dora Nginza Hospital, Port Elizabeth · Livingstone and PE Central Hospitals, Port Elizabeth
Registry updated 2026-06-24
NCT05383742
Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
Trial Treatment · Phase 2 · National Institute of Allergy and Infectious Diseases (NIAID)
Durban International CRS (Site ID:11201), Durban · University of the Witwatersrand Helen Joseph (WITS HJH) CRS (Site ID: 11101), Johannesburg
Registry updated 2026-06-02
NCT05633056
An Adaptive Randomized Controlled Trial
Trial Treatment · Columbia University
King DinuZulu Hospital, Durban
Registry updated 2026-05-28
NCT07602673
Pulmonary Rehabilitation in African Countries
Trial Treatment · University of Edinburgh
Chris Hani Baragwanath Academic Hospital, Johannesburg
Registry updated 2026-05-22
NCT03474029
Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI
Trial Treatment · Phase 2/3 · Centers for Disease Control and Prevention
Desmond Tutu TB Center, Stellenbosch
Registry updated 2026-05-06
NCT04700579
Pre- and Post-treatment Lung Microbiota, Metabolome and Immune Signatures at the Site of Disease in Patients With Active Pulmonary Tuberculosis
Research · University of Stellenbosch
Scottsdene Clinic, Cape Town · Wallacedene Clinic, Cape Town · Kraaifontein Community Health Centre, Cape Town
Registry updated 2026-05-06
NCT04923958
Rapid Research in Diagnostics Development for TB Network
Trial Treatment · University of California, San Francisco
Brooklyn Chest Hospital, Cape Town · Khayelitsha District Health Center, Cape Town · Kraaifontein Community Health Clinic, Cape Town · Wallacedene primary care clinic, Cape Town · Scottsdene primary care clinic, Cape Town
Registry updated 2026-05-06
NCT05007795
Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis
Trial Treatment · University of Cape Town
University of Cape Town, Cape Town
Registry updated 2026-05-06
NCT05317247
Cough Audio Classification as a TB Triage Test
Research · University of Stellenbosch
Stellenbosch University, Cape Town
Registry updated 2026-05-06

All Tuberculosis trials and the map

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