What does science say about Vitamin C (incl. high-dose) and cancer (all types)?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed342studies
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed415studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed379studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 22 · as of 11 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 1 · as of 11 Nov 2026 · Open the search at EU CTISBy phase:Phase 2 (12)Phase 1 (7)Phase 1/2 (2)Early Phase 1 (2)By status:Running, not recruiting (6)Recruiting (6)Completed (4)Stopped early (3)Withdrawn before start (2)Not yet recruiting (1)Paused (1)Countries (6):United States (19)Canada (1)China (1)Denmark (1)Italy (1)Sweden (1)With a linked publication (results): 3 of 23The registries do not tell us here whether results were posted; a linked publication is shown instead.23trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Cancer here means all 33 cancer types we cover.
Examples of what we found
The trials
Phase 2
NCT + PD1 + Ketogenic Diet and/or Vitamin C for LARC
Not yet recruiting · China
ClinicalTrials.gov · NCT07765667Phase 1
A Safety Study of Pharmacologic Ascorbate and Ferumoxytol in Addition to Standard of Care Chemoradiation in Glioblastoma
Running, not recruiting · United States
ClinicalTrials.gov · NCT04900792Phase 1
SHARON: A Clinical Trial for Metastatic Cancer Using Chemotherapy and Patients' Own Stem Cells
Recruiting · United States
ClinicalTrials.gov · NCT04150042Early Phase 1
Gemcitabine Plus Ascorbate for Sarcoma in Adults (Pilot)
Running, not recruiting · United States
ClinicalTrials.gov · NCT04634227Phase 1/2
Intravenous (IV) Vitamin C With Chemotherapy for Cisplatin Ineligible Bladder Cancer Patients
Running, not recruiting · United States
ClinicalTrials.gov · NCT04046094Phase 2
Combining Active and Passive DNA Hypomethylation
Recruiting · Denmark, Sweden
ClinicalTrials.gov · NCT03999723Phase 2
A Phase 2 Study Adding Ascorbate to Chemotherapy and Radiation Therapy for NSCLC
Running, not recruiting · United States
ClinicalTrials.gov · NCT02905591Phase 2
A Phase 2 Trial of High-Dose Ascorbate in Glioblastoma Multiforme
Running, not recruiting · United States
ClinicalTrials.gov · NCT02344355Phase 2
A Clinical Trial Evaluating the Effect of Pharmacological Ascorbate on Radiation Therapy for Pancreatic Cancer Patients
Withdrawn before start · United States
ClinicalTrials.gov · NCT03541486Phase 2
Adjunctive Intravenous Ascorbic Acid for Advanced Non-Small Cell Lung Cancer
Stopped early · Canada
ClinicalTrials.gov · NCT05849129Phase 1
Ascorbate With Durvalumab in Non-Small Cell Lung Cancer (NSCLC)
Stopped early · United States
ClinicalTrials.gov · NCT06083454Phase 2
Phase II Study of PARP Inhibitor Olaparib and IV Ascorbate in Castration Resistant Prostate Cancer
Stopped early · United States
ClinicalTrials.gov · NCT05501548Early Phase 1
Gemcitabine With Ascorbate Including Adolescents
Withdrawn before start · United States
ClinicalTrials.gov · NCT04877587Phase 1/2
High Dose Ascorbate With Preoperative Radiation in Patients With Locally Advanced Soft Tissue Sarcomas
Completed · United States
ClinicalTrials.gov · NCT03508726Phase 1
High Dose Ascorbic Acid for Plasma Cell Disorders
Completed · United States
ClinicalTrials.gov · NCT03602235Phase 2
A Phase 2 Trial of High-dose Ascorbate for Pancreatic Cancer (PACMAN 2.1)
Completed · United States
ClinicalTrials.gov · NCT02905578Phase 1
Gemcitabine, Ascorbate, Radiation Therapy for Pancreatic Cancer, Phase I
Completed · United States
ClinicalTrials.gov · NCT01852890
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Not medical advice. Talk to the care team before changing treatment.