What does science say about Metformin and Multiple sclerosis?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 6 Nov 2026 · Open the search at PubMed1study
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 6 Nov 2026 · Open the search at PubMed12studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 6 Nov 2026 · Open the search at PubMed6studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 6 · as of 6 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 0 · as of 6 Nov 2026 · Open the search at EU CTISBy phase:Phase 2 (4)Early Phase 1 (1)Phase 1/2 (1)By status:Completed (3)Recruiting (2)Running, not recruiting (1)Countries (5):United States (2)Belgium (1)Canada (1)Egypt (1)United Kingdom (1)With a linked publication (results): 3 of 6The registries do not tell us here whether results were posted; a linked publication is shown instead.6trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Examples of what we found
The trials
Phase 2
Metformin as an add-on or Monotherapy in Treatment of Aging People With Multiple Sclerosis (MS)
Recruiting · United States
ClinicalTrials.gov · NCT06463743Phase 2
Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration
Running, not recruiting · Belgium
ClinicalTrials.gov · NCT05893225Early Phase 1
Metformin Treatment in Progressive Multiple Sclerosis
Completed · United States
ClinicalTrials.gov · NCT05349474Phase 2
CCMR Two: A Phase IIa, Randomised, Double-blind, Placebo-controlled Trial of the Ability of the Combination of Metformin and Clemastine to Promote Remyelination in People With Relapsing-remitting Multiple Sclerosis Already on Disease-modifying Therapy
Completed · United Kingdom
ClinicalTrials.gov · NCT05131828
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Other treatments people ask about
- Cannabis and cannabinoids (CBD, THC)Step: Large trials
- Curcumin (turmeric)Step: Large trials
- Fasting and fasting-mimicking dietStep: Large trials
- Ketogenic dietStep: Large trials
- MelatoninStep: Large trials
- MetforminStep: Large trials
- StatinsStep: Large trials
- Vitamin DStep: Large trials
- High-dose vitamin CStep: Reports in people
- HyperthermiaStep: Reports in people
- Mistletoe extractStep: Reports in people
- FenbendazoleStep: Animal studies only
- IvermectinStep: Animal studies only
Not medical advice. Talk to the care team before changing treatment.