What does science say about Metformin and Type 1 diabetes?
- We don’t say yes or no. We show what has been studied.
- Working in a lab or in animals does not mean it works in people.
- Don’t stop or change your treatment without talking to your doctor.
What has been studied
- Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 10 Nov 2026 · Open the search at PubMed1study
- Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 10 Nov 2026 · Open the search at PubMed34studies
- Studies in peoplePublished studies with human participants.Source: PubMed · as of 10 Nov 2026 · Open the search at PubMed117studies
- Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 10 · as of 10 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 0 · as of 10 Nov 2026 · Open the search at EU CTISBy phase:Phase 3 (3)Phase 4 (2)No phase (2)Phase 2/3 (1)Phase 1 (1)Phase 2 (1)By status:Completed (4)Recruiting (3)Running, not recruiting (2)Withdrawn before start (1)Countries (5):United States (4)Iraq (2)Spain (1)France (1)Kazakhstan (1)With a linked publication (results): 1 of 10The registries do not tell us here whether results were posted; a linked publication is shown instead.10trials
- Approved treatmentApproved by a medicines regulator for this disease.No
Examples of what we found
The trials
No phase
Improving Cardiovascular Disease Diagnosis and Treatment in Kazakhstan Using Metabolic Correction With GLP-1 Drugs
Running, not recruiting · Kazakhstan
ClinicalTrials.gov · NCT07303556Phase 2
The Gut Microbiome in Type 1 Diabetes and Mechanism of Metformin Action
Recruiting · United States
ClinicalTrials.gov · NCT05414409Phase 3
Impact of Metformin on Peripheral Arterial Calcification in Type 1 Diabetes
Running, not recruiting · France
ClinicalTrials.gov · NCT04583462Phase 2/3
Oral Hypoglycemic Therapy for Monogenic Variant Carriers of the Joslin Medalist Study
Completed · United States
ClinicalTrials.gov · NCT04409795Phase 3
Incretin Hormones in Type 1 Diabetes Mellitus;Effect of Metformin Treatment
Withdrawn before start
ClinicalTrials.gov · NCT04177303Phase 4
Metformin for Preeclampsia Prevention in Pregnant Women With Type 1 Diabetes Mellitus
Completed · United States
ClinicalTrials.gov · NCT03570632
Thinking of paying for it? Read this first
- Ask for published results. Stories, thank-you letters and "patients report" are not results. Ask where the results were published.
- Know what you pay for. Ask in writing: what exactly is included, who gets the money, and what happens if you stop.
- Ask your own doctor first. Some products interfere with chemotherapy, radiation or other medicines. Your treating doctor can check this.
- Do not stop standard treatment for it. Do not stop or delay your treatment without talking to your care team.
Other treatments people ask about
- Cannabis and cannabinoids (CBD, THC)Step: Large trials
- Fasting and fasting-mimicking dietStep: Large trials
- High-dose vitamin CStep: Large trials
- MelatoninStep: Large trials
- MetforminStep: Large trials
- StatinsStep: Large trials
- Vitamin DStep: Large trials
- Dichloroacetate (DCA)Step: First trials in people
- HyperthermiaStep: First trials in people
- Ketogenic dietStep: Reports in people
- MebendazoleStep: Reports in people
- Curcumin (turmeric)Step: Animal studies only
- FenbendazoleStep: Animal studies only
Not medical advice. Talk to the care team before changing treatment.