What science says

What does science say about Vitamin E and Fatty liver disease (MASLD/MASH)?

We don’t say yes or no. We show what has been studied.
Working in a lab or in animals does not mean it works in people.
Don’t stop or change your treatment without talking to your doctor.

What has been studied

Lab studies (cells)Tests on cells in a dish.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed4studies
Animal studiesTests in mice, rats or other animals.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed45studies
Studies in peoplePublished studies with human participants.Source: PubMed · as of 11 Nov 2026 · Open the search at PubMed115studies
Registered trials in peopleTrials entered in a public registry, whatever their result.ClinicalTrials.gov: 12 · as of 11 Nov 2026 · Open the search at ClinicalTrials.govEU CTIS: 0 · as of 11 Nov 2026 · Open the search at EU CTISBy phase:Phase 2 (8)Phase 4 (2)No phase (1)Phase 3 (1)By status:Completed (7)Running, not recruiting (2)Not yet recruiting (2)Recruiting (1)Countries (5):Egypt (6)Malaysia (2)United States (2)China (1)Pakistan (1)With a linked publication (results): 3 of 12The registries do not tell us here whether results were posted; a linked publication is shown instead.12trials
Approved treatmentApproved by a medicines regulator for this disease.No

Source: PubMed, ClinicalTrials.gov, EU CTIS · as of 11 Nov 2026

Examples of what we found

The trials

2026
Phase 3
Vitamin E Versus Silymarin in Non Diabetic MASLD Patients
Not yet recruiting · Egypt
ClinicalTrials.gov · NCT07863648
2026
Phase 2
The Efficacy of Tocotrienol Rich Fraction for Liver Protection in Adult Patients With Alcoholic Fatty Liver Disease (AFLD)
Not yet recruiting · Malaysia
ClinicalTrials.gov · NCT07466485
2026
Phase 2
A Study of Chiglitazar in Patients With Metabolic Dysfunction-associated Steatohepatitis and Type 2 Diabetes Mellitus
Recruiting · China
ClinicalTrials.gov · NCT07303803
2022
Phase 2
Comparative Study Between Febuxostat Versus Vitamin E in Non-alcoholic Steatohepatitis Patients With Hyperuricemia
Running, not recruiting · Egypt
ClinicalTrials.gov · NCT05574036
2021
Phase 2
Comparative Study Between Obeticholic Acid Versus Vitamin E in Patients with Non-alcoholic Steatohepatitis
Running, not recruiting · Egypt
ClinicalTrials.gov · NCT05573204
2023
Phase 2
Comparison of Effectiveness of Obeticholic Acid With Vitamin E in Patients of Non-alcoholic Fatty Liver Disease
Completed · Pakistan
ClinicalTrials.gov · NCT07104786
2023
Phase 4
Ketotifen in Non-Alcoholic Fatty Liver Disease Patients
Completed · Egypt
ClinicalTrials.gov · NCT05616442
2023
Phase 4
Semaglutide in Nonalcoholic Fatty Liver Disease
Completed · Egypt
ClinicalTrials.gov · NCT05813249
2022
Phase 2
Vitamin E Dosing Study
Completed · United States
ClinicalTrials.gov · NCT04801849
2022
Phase 2
Evaluating the Efficacy and Safety of Roflumilast in Patients with NASH
Completed · Egypt
ClinicalTrials.gov · NCT06677788
2020
No phase
Tocotrienol as a Treatment for Non-alcoholic Fatty Liver Disease
Completed · Malaysia
ClinicalTrials.gov · NCT06596382
2019
Phase 2
Tocotrienol Against the Progression of End Stage Liver Disease
Completed · United States
ClinicalTrials.gov · NCT02581085

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