Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Vitamin C (incl. high-dose) helps with Thyroid cancer.
What has been studied
- 3In people2 randomised trials
- 4In animals
- 5Only in the lab
What the studies found
Vitamin C (incl. high-dose) has been tested in randomised trials in people with Thyroid cancer.
We found 21 published papers on Vitamin C (incl. high-dose) and Thyroid cancer. They were published between 1980 and 2026.
3 of them are studies in people (2 randomised trials), 1 are reviews, 4 are studies in animals and 5 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- The evaluation of protective and mitigating effects of vitamin C against side effects induced by radioiodine therapy.2018 · Radiat Environ Biophys · Randomised trial
- Influence of vitamin C on salivary absorbed dose of 131I in thyroid cancer patients: a prospective, randomized, single-blind, controlled trial.2010 · J Nucl Med · Randomised trial
- Radioiodine-induced oxidative stress in patients with differentiated thyroid carcinoma and effect of supplementation with vitamins C and E and selenium (antioxidants).2016 · Arch Endocrinol Metab · Study in people
- Vitamin C in the Management of Thyroid Cancer: A Highway to New Treatment?2024 · Antioxidants (Basel) · Review
- Vitamin C sensitizes BRAFV600E thyroid cancer to PLX4032 via inhibiting the feedback activation of MAPK/ERK signal by PLX4032.2021 · J Exp Clin Cancer Res · In animals
- Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms.2019 · Theranostics · In animals
- Enhancement of 211At Uptake via the Sodium Iodide Symporter by the Addition of Ascorbic Acid in Targeted α-Therapy of Thyroid Cancer.2019 · J Nucl Med · In animals
- Modification by sodium L-ascorbate, butylated hydroxytoluene, phenobarbital and pepleomycin of lesion development in a wide-spectrum initiation rat model.1989 · Cancer Lett · In animals
- Vitamin C Cytotoxicity and Its Effects in Redox Homeostasis and Energetic Metabolism in Papillary Thyroid Carcinoma Cell Lines.2021 · Antioxidants (Basel) · In the lab
- Vitamin C induces ferroptosis in anaplastic thyroid cancer cells by ferritinophagy activation.2021 · Biochem Biophys Res Commun · In the lab
- Juglone-ascorbic acid synergy inhibits metastasis and induces apoptotic cell death in poorly differentiated thyroid carcinoma by perturbing SOD and catalase activities.2018 · J Biochem Mol Toxicol · In the lab
- Expression of hypoxia inducible factor 1α and 2α and its association with vitamin C level in thyroid lesions.2017 · J Biomed Sci · In the lab
- 6-Deoxy-6-[18F]fluoro-L-ascorbic acid PET/CT in postoperative metastatic differentiated thyroid cancer: a comparative study with fluorine-18 fluorodeoxyglucose.2026 · Eur Radiol · Other paper
- 6-Deoxy-6-[ 18 F]Fluoro-L-Ascorbic Acid PET/CT in the Detection of Lymph Node Metastases for Postoperative Differentiated Thyroid Cancer Patients : Using Histopathology as Reference Standard.2025 · Clin Nucl Med · Other paper
- Exploring the mechanism of vitamin C on the co-expressed genes of papillary thyroid carcinoma and Epstein-Barr virus based on bioinformatics, network pharmacology and molecular docking analysis.2025 · Discov Oncol · Other paper
- Optimal administration time of vitamin C after 131I therapy in differentiated thyroid cancer based on propensity score matching.2022 · Front Surg · Other paper