Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Omega-3 fatty acids (fish oil) helps with Atrial fibrillation.
What has been studied
- 32In people31 randomised trials
- 9In animals
- 0Only in the lab
What the studies found
Omega-3 fatty acids (fish oil) has been tested in randomised trials in people with Atrial fibrillation.
We found 147 published papers on Omega-3 fatty acids (fish oil) and Atrial fibrillation. They were published between 2005 and 2026.
32 of them are studies in people (31 randomised trials), 41 are reviews, 9 are studies in animals and 0 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Effect of Omega-3 Fatty Acid Intake on Circulating Biomarkers of Atrial Fibrillation-Related Pathways in the PREDIMED-Plus Study.2026 · Nutrients · Randomised trial
- Omega-3 fatty acid supplements and risk of atrial fibrillation and 'micro-atrial fibrillation': A secondary analysis from the OMEMI trial.2023 · Clin Nutr · Randomised trial
- Cardiovascular Benefits of Icosapent Ethyl in Patients With and Without Atrial Fibrillation in REDUCE-IT.2023 · J Am Heart Assoc · Randomised trial
- Changes in eicosapentaenoic acid and docosahexaenoic acid and risk of cardiovascular events and atrial fibrillation: A secondary analysis of the OMEMI trial.2022 · J Intern Med · Randomised trial
- Omega-3 polyunsaturated fatty acid supplementation improves lipid metabolism and endothelial function by providing a beneficial eicosanoid-pattern in patients with acute myocardial infarction: A randomized, controlled trial.2021 · Clin Nutr · Randomised trial
- Assessment of OMT-28, a synthetic analog of omega-3 epoxyeicosanoids, in patients with persistent atrial fibrillation: Rationale and design of the PROMISE-AF phase II study.2020 · Int J Cardiol Heart Vasc · Randomised trial
- Effect of fish oil on circulating asymmetric dimethylarginine and adiponectin in overweight or obese patients with atrial fibrillation.2020 · Food Sci Nutr · Randomised trial
- Fish Oil Supplementation Does Not Affect Cognitive Outcomes in Cardiac Surgery Patients in the Omega-3 Fatty Acids for Prevention of Post-Operative Atrial Fibrillation (OPERA) Trial.2018 · J Nutr · Randomised trial
- Preoperative carbohydrate load and intraoperatively infused omega-3 polyunsaturated fatty acids positively impact nosocomial morbidity after coronary artery bypass grafting: a double-blind controlled randomized trial.2017 · Nutr J · Study in people
- Fish oil supplementation for primary prevention of atrial fibrillation after coronary artery bypass graft surgery: A randomized clinical trial.2017 · Int J Surg · Study in people
- Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 35 Trials including 114 592 Individuals.2026 · Circ Arrhythm Electrophysiol · Review
- Effects of Omega-3 Fatty Acid Treatment on Risk for Atrial Fibrillation: An Updated Meta-Analysis of 34 Trials including 114,326 Individuals.2025 · medRxiv · Review
- Does parenteral Omega-3 fatty acid administration increase the risk of atrial fibrillation? An analysis of the current evidence.2025 · Clin Nutr · Review
- A review of the relationships between reported fish oil supplement use and health outcomes in the UK Biobank.2025 · Prostaglandins Leukot Essent Fatty Acids · Review
- Omega-3 and Risk of atrial fibrillation: Vagally-mediated double-edged sword.2025 · Prog Cardiovasc Dis · Review
- Omega-3 Fatty Acids and Arrhythmias.2024 · Circulation · Review
- Physiological doses of eicosapentaenoic acid suppress high-fat diet-induced atrial fibrillation in mice independent of lipid lowering.2026 · J Physiol Sci · In animals
- Eicosapentaenoic acid prevents atrial electrocardiographic impairments and atrial fibrillation in high fat diet mice.2025 · J Physiol Sci · In animals
- Fish, long-chain omega-3 polyunsaturated fatty acid intake and incidence of atrial fibrillation: A pooled analysis of two prospective studies.2017 · Clin Nutr · In animals
- [Effects of docosahexaenoic acid on atrial physiological parameter and TASK-1 protein expression in atrial fibrillation rats].2016 · Zhongguo Ying Yong Sheng Li Xue Za Zhi · In animals
- Docosahexaenoic acid, but not eicosapentaenoic acid, supplementation reduces vulnerability to atrial fibrillation.2012 · Circ Arrhythm Electrophysiol · In animals
- Eicosapentaenoic acid prevents atrial fibrillation associated with heart failure in a rabbit model.2011 · Am J Physiol Heart Circ Physiol · In animals
- Omega-3 Fatty Acids and Atrial Fibrillation: Current Evidence and Expert Opinion.2026 · Eur J Prev Cardiol · Other paper
- Association Between Plasma Omega-3 and Omega-6 Fatty Acid Levels and Atrial Fibrillation: A Large-Scale, Real-World Retrospective Study in Japan.2026 · J Atheroscler Thromb · Other paper
- Phenotypic age acceleration and omega-6/omega-3 PUFA ratio in dynamic atrial fibrillation-heart failure transitions: a multistate analysis.2026 · J Nutr Health Aging · Other paper
- Associations Between Plasma Omega-3 and Fish Oil Use With Risk of Atrial Fibrillation in the UK Biobank.2025 · J Am Heart Assoc · Other paper