Stem cell treatment & Crohn's disease

Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.

What people read

Posts online say that Stem cell treatment helps with Crohn's disease.

What has been studied

• 17In people7 randomised trials
• 9In animals
• 3Only in the lab

What the studies found

!Stem cell treatment has been tested in randomised trials in people with Crohn's disease.

We found 153 published papers on Stem cell treatment and Crohn's disease. They were published between 2004 and 2026.

17 of them are studies in people (7 randomised trials), 66 are reviews, 9 are studies in animals and 3 are studies only in the lab.

The most important ones are listed under Sources.

Sources

1. Darvadstrocel in Patients With Crohn's Disease With Complex Perianal Fistulas: The ADMIRE CD II Phase 3 Randomized Trial.2026 · Gastroenterology · Randomised trial
2. Safety and efficacy of autologous haematopoietic stem-cell transplantation with low-dose cyclophosphamide mobilisation and reduced intensity conditioning versus standard of care in refractory Crohn's disease (ASTIClite): an open-label, multicentre, randomised controlled trial.2024 · Lancet Gastroenterol Hepatol · Randomised trial
3. A phase IB/IIA study of ex vivo expanded allogeneic bone marrow-derived mesenchymal stem cells for the treatment of rectovaginal fistulizing Crohn's disease.2024 · Surgery · Randomised trial
4. A Phase IB/IIA Study of Allogeneic, Bone Marrow-derived, Mesenchymal Stem Cells for the Treatment of Refractory Ileal-anal Anastomosis and Peripouch Fistulas in the Setting of Crohn's Disease of the Pouch.2023 · J Crohns Colitis · Randomised trial
5. Cx601 (darvadstrocel) for the treatment of perianal fistulizing Crohn's disease.2019 · Expert Opin Biol Ther · Randomised trial
6. Umbilical Cord Mesenchymal Stem Cell Treatment for Crohn's Disease: A Randomized Controlled Clinical Trial.2018 · Gut Liver · Randomised trial
7. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.2016 · Lancet · Randomised trial
8. Rationale and design of the AlloFIST trial: a phase I/IIa study to evaluate dose escalation of allogeneic adipose-derived stroma/stem cells for the treatment of Crohn's fistula.2025 · BMJ Open · Study in people
9. Reparative immunological consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease.2025 · Gut · Study in people
10. Efficacy and safety of allogeneic umbilical cord-derived mesenchymal stem cells for the treatment of complex perianal fistula in Crohn's disease: a pilot study.2023 · Stem Cell Res Ther · Study in people
11. A Phase I Study of Ex Vivo Expanded Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells for the Treatment of Pediatric Perianal Fistulizing Crohn's Disease.2023 · Inflamm Bowel Dis · Study in people
12. Clinical and MRI Evolution After Local Injection of Bone Marrow-Derived Mesenchymal Stem Cells in Perianal Fistulae in Crohn's Disease: Results From a Prospective Monocentric Study.2023 · J Crohns Colitis · Study in people
13. Safety and efficacy of injection of human placenta mesenchymal stem cells derived exosomes for treatment of complex perianal fistula in non-Crohn's cases: Clinical trial phase I.2023 · J Gastroenterol Hepatol · Study in people
14. Long-term clinical outcomes of stem cell-based interventions in Crohn's-related perianal fistula: A systematic review and meta-analysis.2026 · Colorectal Dis · Review
15. Efficacy and safety of tumor necrosis factor-α inhibitors and mesenchymal stem cells in the treatment of fistulizing Crohn's disease: a systematic review and network meta-analysis.2026 · Front Immunol · Review
16. Needles for healing: stem cells, platelet-enriched plasma, and fat injection in perianal fistulizing Crohn's disease.2026 · Tech Coloproctol · Review
17. The efficacy of adipose-derived stem cell therapy for complex perianal fistulas in Crohn's disease patients: A systematic review.2026 · Surg Open Sci · Review
18. Therapeutic potential and mechanistic insights into adipose-derived stem cells and mesenchymal stem cell-derived exosomes in patients with Crohn's disease-associated fistulas: challenges and future perspectives.2025 · Stem Cell Res Ther · Review
19. Stem cell- and extracellular vesicle-based therapies for perianal fistulizing Crohn's disease: An updated review.2025 · World J Gastroenterol · Review
20. Mesenchymal Stem Cells Alleviate Crohn's Disease by Regulating CBS-Mediated Ferroptosis.2026 · Immun Inflamm Dis · In animals
21. Mesenchymal stem cell-derived exosomes derived from induced pluripotent stem cells ameliorate inflammation and promote mucosal healing via miR-34a-5p in Crohn disease.2026 · Inflamm Bowel Dis · In animals
22. A cell-free TLR5high MSC membrane nanoparticle therapy for Crohn's disease: Targeted immunomodulation via the flagellin/TLR5 axis.2025 · J Control Release · In animals
23. Human placenta mesenchymal stromal cells alleviate intestinal inflammation and repair intestinal barrier function by activating AMPK-FXR pathway.2025 · Commun Biol · In animals
24. Extracellular vesicles derived from creeping fat stem cells promote lymphatic function and restrain inflammation of Crohn's disease.2024 · Clin Transl Med · In animals
25. Small extracellular vesicles derived from adipose mesenchymal stem cells alleviate intestinal fibrosis by inhibiting the FAK/Akt signaling pathway via MFGE8.2024 · J Gastroenterol · In animals
26. Eicosatetraynoic Acid Regulates Profibrotic Pathways in an Induced Pluripotent Stem Cell-Derived Macrophage-Human Intestinal Organoid Model of Crohn's Disease.2025 · J Crohns Colitis · In the lab
27. TNFα Induces LGR5+ Stem Cell Dysfunction In Patients With Crohn's Disease.2022 · Cell Mol Gastroenterol Hepatol · In the lab
28. Anti-fibrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn's Disease.2018 · Dig Dis Sci · In the lab
29. Calprotectin levels in Crohn's perianal fistula scraping are associated with fistula outcomes after surgical closure.2026 · Colorectal Dis · Other paper
30. Outcomes of autologous hematopoietic stem cell transplantation in patients with refractory Crohn's disease: a single-center retrospective case series.2026 · Acta Gastroenterol Belg · Other paper
31. Clinical Remission of Crohn's Disease and Closure of a Rectovaginal Fistula After Autologous Non-Myeloablative Hematopoietic Stem Cell Transplantation.2026 · Int Med Case Rep J · Other paper
32. Interpreting a Negative Trial in Complex Perianal Crohn's Disease: The End of Allogenic Stem Cell Treatment for Fistula Patients?2026 · Gastroenterology · Other paper

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