Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Stem cell treatment helps with Sjögren's disease.
What has been studied
- 4In people3 randomised trials
- 35In animals
- 5Only in the lab
What the studies found
Stem cell treatment has been tested in randomised trials in people with Sjögren's disease.
We found 77 published papers on Stem cell treatment and Sjögren's disease. They were published between 2001 and 2026.
4 of them are studies in people (3 randomised trials), 25 are reviews, 35 are studies in animals and 5 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Efficacy of topical mesenchymal stem cell exosome in Sjögren's syndrome-related dry eye: a randomized clinical trial.2025 · BMC Ophthalmol · Randomised trial
- Allogeneic mesenchymal stem cell therapy for dry eye disease in patients with Sjögren's syndrome: A randomized clinical trial.2024 · Ocul Surf · Randomised trial
- Effect of adipose tissue-derived stem cells therapy on clinical response in patients with primary Sjogren's syndrome.2023 · Sci Rep · Randomised trial
- A first-in-human, prospective pilot trial of umbilical cord-derived mesenchymal stem cell eye drops therapy for patients with refractory non-Sjögren's and Sjögren's syndrome dry eye disease.2025 · Stem Cell Res Ther · Study in people
- The Efficacy of Mesenchymal Stem Cell-Based Therapy for Sjögren's Syndrome: A Systematic Review and Meta-Analysis of Preclinical Studies.2026 · Int Dent J · Review
- Efficacy and safety of stem cell therapy for dry eye syndrome in Sjögren's syndrome: a systematic review and meta-analysis.2026 · Front Immunol · Review
- Treatment of Xerostomia with Mesenchymal Stem Cells - A Systematic Review and Meta-Analysis of Clinical Trials.2026 · Stem Cell Rev Rep · Review
- Targeted Therapy for Severe Sjogren's Syndrome: A Focus on Mesenchymal Stem Cells.2024 · Int J Mol Sci · Review
- Cell therapy in Sjögren's syndrome: opportunities and challenges.2024 · Expert Rev Mol Med · Review
- Adipose derived or bone-marrow derived mesenchymal stem cell treatment for hyposalivation: protocol for a systematic review and network meta-analysis.2024 · Syst Rev · Review
- Tripterygium glycosides and mesenchymal stem cells combination alleviated Sjögren's syndrome Features in mice and modulated the GRO-α/CXCR2 axis.2026 · Am J Transl Res · In animals
- Mesenchymal stem cells ameliorate Sjögren disease by suppressing B cells through the Pik3cb/Akt/mTOR pathway.2026 · Front Immunol · In animals
- Exosomes derived from stem cells from apical papilla reduce Th17 cell differentiation and hyposalivation in a murine model of Sjögren's disease.2026 · BMC Oral Health · In animals
- The Effects of Mesenchymal Stem Cell-Derived Exosomes on the Attenuation of Dry Eye Disease in Sjögren Syndrome Animal Model.2025 · Tissue Eng Regen Med · In animals
- Route of Application and Dose Evaluation of Dental Pulp Stem Cells for the Treatment of Sialadenitis Caused by Sjögren's Syndrome: A Preclinical Study.2025 · Biomedicines · In animals
- The impact of alternate-day fasting on the salivary gland stem cell compartments in non-obese diabetic mice with newly established Sjögren's syndrome.2024 · Biochim Biophys Acta Mol Cell Res · In animals
- Immunoregulatory effects of dental mesenchymal stem cells on T and B lymphocyte responses in primary Sjögren's syndrome.2022 · Immunotherapy · In the lab
- Mesenchymal stem cells negatively regulate CD4+ T cell activation in patients with primary Sjögren syndrome through the miRNA‑125b and miRNA‑155 TCR pathway.2021 · Mol Med Rep · In the lab
- MIST1, an Inductive Signal for Salivary Amylase in Mesenchymal Stem Cells.2019 · Int J Mol Sci · In the lab
- Characteristics of Labial Gland Mesenchymal Stem Cells of Healthy Individuals and Patients with Sjögren's Syndrome: A Preliminary Study.2017 · Stem Cells Dev · In the lab
- Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cells Transplantation into the Lacrimal Gland in Patients with Sjögren Syndrome.2026 · Korean J Ophthalmol · Other paper
- Mesenchymal stromal cells attenuate primary sjogren's syndrome by modulating PD-1+CXCR5- T peripheral helper cells via galectin-1.2025 · Stem Cell Res Ther · Other paper
- Correction: Dental follicle mesenchymal stem cells ameliorated glandular dysfunction in Sjögren's syndrome murine model.2024 · PLoS One · Other paper
- Autologous haematopoietic stem cell transplantation for primary Sjögren's syndrome with severe refractory thrombocytopenia: a case report.2023 · Clin Exp Rheumatol · Other paper