Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Stem cell treatment helps with Systemic sclerosis (scleroderma).
What has been studied
- 9In people4 randomised trials
- 18In animals
- 2Only in the lab
What the studies found
Stem cell treatment has been tested in randomised trials in people with Systemic sclerosis (scleroderma).
We found 184 published papers on Stem cell treatment and Systemic sclerosis (scleroderma). They were published between 1997 and 2026.
9 of them are studies in people (4 randomised trials), 69 are reviews, 18 are studies in animals and 2 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- A composite biomarker score to predict modified Rodnan skin score in systemic sclerosis: insight from autologous stem cell transplantation international scleroderma trial.2025 · Arthritis Res Ther · Randomised trial
- Myeloablation Followed by Hematopoietic Stem Cell Transplantation and Long-Term Normalization of Systemic Sclerosis Molecular Signatures.2024 · Arthritis Rheumatol · Randomised trial
- Clinical and Molecular Findings After Autologous Stem Cell Transplantation or Cyclophosphamide for Scleroderma: Handling Missing Longitudinal Data.2023 · Arthritis Care Res (Hoboken) · Randomised trial
- Autologous hematopoietic stem cell transplantation vs intravenous pulse cyclophosphamide in diffuse cutaneous systemic sclerosis: a randomized clinical trial.2014 · JAMA · Randomised trial
- High-dose chemotherapy and transplantation of autologous CD34+ selected stem cells for progressive systemic sclerosis adjusted to cardiac and lung manifestation: An open-label, non-inferiority phase 2 trial.2026 · Joint Bone Spine · Study in people
- Autologous haematopoietic stem cell transplantation for Japanese patients with systemic sclerosis: Long-term follow-up on a phase II trial and treatment-related fatal cardiomyopathy.2018 · Mod Rheumatol · Study in people
- Sustained benefit from combined plasmapheresis and allogeneic mesenchymal stem cells transplantation therapy in systemic sclerosis.2017 · Arthritis Res Ther · Study in people
- Autologous non-myeloablative hematopoietic stem cell transplantation in patients with systemic sclerosis.2007 · Bone Marrow Transplant · Study in people
- Hematopoietic stem cell transplantation for systemic sclerosis with rapid improvement in skin scores: is neoangiogenesis occurring?2003 · Bone Marrow Transplant · Study in people
- Mesenchymal Stem Cell Therapy for Systemic Sclerosis: Current Evidence and Clinical Applications.2026 · Stem Cell Rev Rep · Review
- Emerging Cell-Based Therapies for Systemic Sclerosis: From Stem Cells to CAR-T Cells.2026 · Curr Issues Mol Biol · Review
- Comparative Efficacy of Autologous Hematopoietic and Mesenchymal Stem Cell Transplantation in Patients with Systemic Sclerosis: A Systematic Review.2025 · J Clin Med · Review
- Autologous Hematopoietic Stem Cell Transplantation in Systemic Sclerosis: Current Evidence and Future Directions.2025 · ACR Open Rheumatol · Review
- Mesenchymal Stem-Cell-Derived Exosomes and MicroRNAs: Advancing Cell-Free Therapy in Systemic Sclerosis.2025 · Cells · Review
- Stem cell therapy in systemic sclerosis.2025 · Clin Rheumatol · Review
- Adipose stem cell vesicles reduce bleomycin-induced dermal fibrosis and oxidative stress in scleroderma mice via circ-Zfyve9.2026 · J Immunol · In animals
- Intralesional Adipose-Derived Stem Cells Reverse Established Dermal Fibrosis and Modulate Angiogenesis-Related Readouts in a Murine Systemic Sclerosis Model.2026 · Tissue Eng Regen Med · In animals
- 3D-Mesenchymal stromal cells derived VASH2 alleviates oxidative stress-induced endothelial senescence by mediating α-tubulin detyrosination in systemic sclerosis.2026 · J Transl Med · In animals
- Time-Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism.2026 · Adv Sci (Weinh) · In animals
- Mesenchymal stem cells attenuate systemic sclerosis related lung fibrosis by inhibiting T follicular helper cells in tertiary lymphoid structure.2026 · Arthritis Res Ther · In animals
- Mesenchymal stromal cells ameliorate systemic sclerosis-interstitial lung disease via PD-1/PD-L1 signalling axis.2026 · RMD Open · In animals
- Association between stem cell growth factor beta and fibrotic skin diseases.2025 · Eur J Dermatol · In the lab
- Autologous haematopoietic stem cell transplantation restores the suppressive capacity of regulatory B cells in systemic sclerosis patients.2021 · Rheumatology (Oxford) · In the lab
- Long-term evaluation of the effectiveness and safety of autologous haematopoietic stem-cell transplantation for systemic sclerosis (NISSC1-LTE): a cohort study.2026 · Lancet Rheumatol · Other paper
- Incidence and characteristics of cytokine release syndrome in patients with systemic sclerosis undergoing autologous haematopoietic stem cell transplantation.2026 · Semin Arthritis Rheum · Other paper
- A new dawn for autologous haematopoietic stem cell transplantation in systemic sclerosis in the era of cellular therapies.2026 · J Scleroderma Relat Disord · Other paper
- Survival and disease reactivation after autologous stem cell transplantation for systemic sclerosis: a single-centre cohort.2026 · EULAR Rheumatol Open · Other paper