Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Stem cell treatment helps with Type 1 diabetes.
What has been studied
- 8In people5 randomised trials
- 47In animals
- 4Only in the lab
What the studies found
Stem cell treatment has been tested in randomised trials in people with Type 1 diabetes.
We found 230 published papers on Stem cell treatment and Type 1 diabetes. They were published between 2002 and 2026.
8 of them are studies in people (5 randomised trials), 142 are reviews, 47 are studies in animals and 4 are studies only in the lab.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Safety and efficacy of human gingiva-derived mesenchymal stem cells in patients with type 1 diabetes: a double-blind, randomized, placebo-controlled, phase 1 trial.2026 · Signal Transduct Target Ther · Randomised trial
- Mesenchymal stem cell transplantation in newly diagnosed type-1 diabetes patients: a phase I/II randomized placebo-controlled clinical trial.2022 · Stem Cell Res Ther · Randomised trial
- Prevention of chronic diabetic complications in type 1 diabetes by co-transplantation of umbilical cord mesenchymal stromal cells and autologous bone marrow: a pilot randomized controlled open-label clinical study with 8-year follow-up.2022 · Cytotherapy · Randomised trial
- Adipose tissue-derived stromal/stem cells + cholecalciferol: a pilot study in recent-onset type 1 diabetes patients.2021 · Arch Endocrinol Metab · Randomised trial
- Preserved β-cell function in type 1 diabetes by mesenchymal stromal cells.2015 · Diabetes · Randomised trial
- Insulin expression and C-peptide in type 1 diabetes subjects implanted with stem cell-derived pancreatic endoderm cells in an encapsulation device.2021 · Cell Rep Med · Study in people
- Allogenic Adipose Tissue-Derived Stromal/Stem Cells and Vitamin D Supplementation in Patients With Recent-Onset Type 1 Diabetes Mellitus: A 3-Month Follow-Up Pilot Study.2020 · Front Immunol · Study in people
- Immune response after autologous hematopoietic stem cell transplantation in type 1 diabetes mellitus.2017 · Stem Cell Res Ther · Study in people
- Engineering stem cell-derived islets for type 1 diabetes: genetic strategies for immune evasion and stress resilience.2026 · Regen Med · Review
- Engineering Immune-Protective Stem Cell-Derived β-Cell Grafts for Type 1 Diabetes: Encapsulation Technologies and the Emerging Graft Ecosystem.2026 · Artif Organs · Review
- Mesenchymal stem cell therapy for diabetes: clinical evidence, emerging strategies, and future perspectives.2026 · Metabolism · Review
- Guiding pluripotent stem cell therapies past the immune system.2026 · Stem Cells Transl Med · Review
- Cell-Based Therapies for Type 1 Diabetes: A Narrative Review of Stem Cell-Derived Islets, Encapsulation Strategies, and Recent Clinical Trials.2026 · Cureus · Review
- Development and trend of stem cell therapy for diabetes: a comprehensive review based on knowledge visualization.2026 · Front Immunol · Review
- AIRE Deficiency Impairs Thymic Epithelial Progenitor Differentiation from Mouse Embryonic Stem Cells and Accelerates Type 1 Diabetes in NOD/Ltj Mice.2026 · Int J Mol Sci · In animals
- Markers of beta cell and alpha cell mass in human stem cell-generated implants with glycemic control at human setpoint.2026 · Stem Cells Transl Med · In animals
- Platelet-Derived Exosome Product Prolongs Stem Cell-Derived β-Cell Graft Survival and Is Associated with Reduced Nk Cell Infiltration and Immunomodulation.2026 · Cells · In animals
- Insulin gene-modified 3D stem cells for enhanced islet regeneration and systemic reversal of type 1 diabetes.2026 · Stem Cells Transl Med · In animals
- Co-transplantation of pancreatic islets with adipose-derived mesenchymal stem cells in vascularized kidney ECM scaffolds to restore type 1 diabetes mellitus.2026 · Bioact Mater · In animals
- Regenerative macrophages enhance stem cell-derived β cell function and engraftment.2026 · Sci Adv · In animals
- Generation of an induced pluripotent stem cell line (SCVli192-A) from a patient with immune checkpoint inhibitor-induced myocarditis and concurrent type 1 diabetes.2026 · Stem Cell Res · In the lab
- Limitations in PPARα-dependent mitochondrial programming restrain the differentiation of human stem cell-derived β cells.2025 · Nat Commun · In the lab
- Herpes Simplex Virus 1 Infection of Human Brain Organoids and Pancreatic Stem Cell-Islets Drives Organoid-Specific Transcripts Associated with Alzheimer's Disease and Autoimmune Diseases.2024 · Cells · In the lab
- Autologous Mesenchymal Stem Cell Transplant in Patients with Type 1 Diabetes Mellitus.2019 · Exp Clin Transplant · In the lab
- [Analysis of efficacy and prognosis of allogeneic hematopoietic stem cell transplantation for immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome].2026 · Zhonghua Er Ke Za Zhi · Other paper
- Severe onset type 1 diabetes mellitus with unusual manifestations due to CD70 deficiency: novel pathway in deciphering the etiopathogenesis of type 1 diabetes mellitus, and the experience with hematopoietic stem cell transplantation.2026 · Pediatr Diabetes · Other paper
- Autologous and allogeneic stem cell-derived islet therapy in three recipients with type 1 diabetes and complete loss of endogenous pancreatic β-cell function pretransplant.2026 · Lancet Diabetes Endocrinol · Other paper
- Adults with type 1 diabetes define what matters to them in stem-cell derived islet cell therapy.2026 · Nat Med · Other paper