Written from the studies on PubMed, searched on 2026. nov. 11.. Every number below comes from a study listed under Sources.
What people read
Posts online say that Stem cell treatment helps with Type 2 diabetes.
What has been studied
- 10In people6 randomised trials
- 48In animals
- 14Only in the lab
What the studies found
Stem cell treatment has been tested in randomised trials in people with Type 2 diabetes.
We found 164 published papers on Stem cell treatment and Type 2 diabetes. They were published between 1998 and 2026.
10 of them are studies in people (6 randomised trials), 69 are reviews, 48 are studies in animals and 14 are studies only in the lab. 1 paper was retracted.
The most important ones are listed under Sources.
What this means for you: A study in people is not proof that it helps you. Do not stop or change your medicines because of it. Ask your doctor before you start taking it.
Sources
- Effect of Mesenchymal Stem Cell Infusion in Stage II-IV Diabetic Nephropathy.2026 · J Coll Physicians Surg Pak · Randomised trial
- Human umbilical cord mesenchymal stromal cells derivatives in treating diabetic foot ulcers: a phase I/II safety and efficacy trial.2025 · Stem Cell Res Ther · Randomised trial
- Bone marrow mesenchymal stem cell and mononuclear cell combination therapy in patients with type 2 diabetes mellitus: a randomized controlled study with 8-year follow-up.2024 · Stem Cell Res Ther · Randomised trial
- Predictive factors that influence the clinical efficacy of umbilical cord-derived mesenchymal stromal cells in the treatment of type 2 diabetes mellitus.2024 · Cytotherapy · Randomised trial
- Efficacy of Umbilical Cord-Derived Mesenchymal Stem Cells in the Treatment of Type 2 Diabetes Assessed by Retrospective Continuous Glucose Monitoring.2023 · Stem Cells Transl Med · Randomised trial
- Type 2 diabetes mellitus duration and obesity alter the efficacy of autologously transplanted bone marrow-derived mesenchymal stem/stromal cells.2021 · Stem Cells Transl Med · Randomised trial
- Safety and efficacy of allogeneic umbilical cord-derived mesenchymal stem cell transplantation in type 2 diabetes: a pilot clinical trial.2025 · Am J Stem Cells · Study in people
- Wharton's jelly mesenchymal stem cells transplantation for critical limb ischemia in patients with type 2 diabetes mellitus: a preliminary report of phase I clinical trial.2024 · Cell Tissue Res · Study in people
- Fetal Pancreatic Stem-Cell Transplant in Patients With Diabetes Mellitus.2015 · Exp Clin Transplant · Study in people
- Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study.2011 · Front Med · Study in people
- Emerging molecular and cellular therapeutics for type 2 diabetes: integrating stem cell and miRNA approaches toward precision medicine.2026 · Stem Cell Res Ther · Review
- Mesenchymal stromal cell-based therapies for obesity-associated metabolic complications: Mechanistic insights, translational evidence, and future perspectives.2026 · Biomed Pharmacother · Review
- Mesenchymal stem cell therapy for diabetes: clinical evidence, emerging strategies, and future perspectives.2026 · Metabolism · Review
- Development and trend of stem cell therapy for diabetes: a comprehensive review based on knowledge visualization.2026 · Front Immunol · Review
- Targeted Strategies of Adipose Stem Cells for Metabolic Diseases: Mechanisms and Clinical Translation Challenges.2026 · Stem Cell Rev Rep · Review
- Patient-derived induced pluripotent stem cells for precision modelling of monogenic beta cell disorders.2026 · Front Endocrinol (Lausanne) · Review
- Oxyberberine Ameliorates Type 2 Diabetic Osteoporosis Through Sirtuin 3-Associated Regulation of Autophagy and Ferroptosis in Bone Marrow Mesenchymal Stem Cells.2026 · Phytother Res · In animals
- Exosomes derived from human umbilical cord mesenchymal stem cells attenuate brain-lung complications in type 2 diabetic rats via suppression of mTOR/GSK3β and TRPM2/NLRP3 pathways.2026 · Arch Physiol Biochem · In animals
- Fine particulate matter accelerates the senescence of bone marrow-conserved stem cells in a type 2 diabetes mellitus mouse model.2026 · J Hazard Mater · In animals
- Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuate Diabetic β-Cell Apoptosis and Dedifferentiation by Delivering miR-4436.2026 · Tissue Eng Regen Med · In animals
- Type 2 Diabetes-Induced Molecular and Functional Impairment of Adipose Tissue-Derived Mesenchymal Stromal Cells (ASCs) and Interferon Gamma Priming for Enhanced Diabetic ASC-Based Therapy.2026 · Stem Cell Rev Rep · In animals
- Type 2 Diabetes Modulates Mesenchymal Stem Cell Response to Advanced Glycation End Products and N-Acetylcysteine Antioxidant Effect.2026 · Pharmaceutics · In animals
- Type 2 diabetes mellitus limits the glucose-responsive β-like functionality but not pancreatic lineage commitment of induced human adipose-derived stem cells.2026 · Int J Biochem Cell Biol · In the lab
- Modeling Genetic Risk of β-Cell Dysfunction in Human Induced Pluripotent Stem Cells From Patients Carrying the MTNR1B Risk Variant.2025 · J Pineal Res · In the lab
- Validation of a physiological type 2 diabetes model in human periodontal ligament stem cells.2024 · Oral Dis · In the lab
- Immunomodulatory Functions of Adipose Mesenchymal Stromal/Stem Cell Derived From Donors With Type 2 Diabetes and Obesity on CD4 T Cells.2023 · Stem Cells · In the lab
- Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation.2021 · Stem Cell Res Ther · RetractedRetracted
- Circadian Rhythms of Clock Genes After Transplantation of Mesenchymal Stem Cells with Type 2 Diabetes Mellitus.2024 · Int J Mol Sci · Other paper
- Cautious Optimism Warranted for Stem Cell-Derived Islet Transplantation in Type 2 Diabetes.2024 · Transpl Int · Other paper
- Functional interrogation of twenty type 2 diabetes-associated genes using isogenic human embryonic stem cell-derived β-like cells.2023 · Cell Metab · Other paper
- Visceral mesenchymal stem cells from type 2 diabetes donors activate triglycerides synthesis in healthy adipocytes via metabolites exchange and cytokines secretion.2023 · Int J Obes (Lond) · Other paper