Új vizsgálatok, publikációk, preprintek és pályázatok ezen a célponton, hónapról hónapra.
Publikáció
Endothelial BACE1 impairs insulin signaling to drive cerebral small vessel disease and stroke.
2026. okt. 16.· Science bulletin· PUBMED
Publikáció
Sulfamethoxazole Attenuates Aluminum-induced Cognitive Impairment: In silico Evidence for BACE1 Interaction and In vivo Behavioral Assessment.
2026. okt. 8.· Current drug targets· PUBMED
Publikáció
Targeting the BACE1-GSK-3β Signaling Axis in Alzheimer's Disease: From Molecular Crosstalk to Nanotechnology-Based Translational Strategies.
2026. szept. 21.· Molecular neurobiology· PUBMED
Publikáció
Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation.
2026. szept. 16.· ACS omega· PUBMED
Publikáció
Design, Synthesis, and Biological Activity of Isothiocyanate-Triazine Conjugates as AChE and BACE1 Inhibitors.
2026. szept. 3.· Biomolecules· PUBMED
Publikáció
Age-dependent biphasic alterations and protein-activity decoupling of plasma BACE1 in major depressive disorder.
2026. aug. 26.· Frontiers in psychiatry· PUBMED
Publikáció
Leveraging molecular dynamics to unravel the inhibition mechanism of potential β-secretase (BACE1) inhibitors.
2026. aug. 26.· Physical chemistry chemical physics : PCCP· PUBMED
Publikáció
A self-powered photoelectrochemical sensor with ultra-low background based on ZnIn2S4@CdS photoanode and Bi2WO6 photocathode for BACE1 detection.
2026. aug. 14.· Biosensors & bioelectronics· PUBMED
Publikáció
Integrated Virtual Screening and Molecular Electrostatic Surface Potential Descriptors for Predicting BACE1 Inhibitor Interactions in Alzheimer's Disease.
2026. aug. 7.· ACS omega· PUBMED
Publikáció
ARG128-associated recognition of nobiletin by BACE1 revealed by triplicate molecular dynamics, MM-GBSA, and residue-level decomposition.
2026. aug. 7.· Molecular diversity· PUBMED
Publikáció
Cannabis flower extracts as a multi-target agent in Alzheimer's disease: Inhibition of AChE, BChE, and BACE1 with cell-protective effects in a PC12 cell model.
2026. júl. 31.· Journal of cannabis research· PUBMED
Publikáció
Development of a Novel AAV-Mediated microRNA Gene Therapy for Spatial Suppression of BACE1 to Improve Cognitive Function in Alzheimer's Disease Model Mice.
2026. júl. 23.· Biomolecules· PUBMED
Publikáció
Robust multi-parameter classification-QSAR-based prioritization: Evaluating ranking stability under weight uncertainty for BACE1 inhibitor discovery.
2026. júl. 17.· Computational biology and chemistry· PUBMED
Publikáció
Unveiling the structural insights and inhibitory potential of coumarin-1,2,3-triazole hybrids against BACE1: a promising approach for Alzheimer's disease therapy.
2026. júl. 7.· Frontiers in chemistry· PUBMED
Publikáció
A 19F MRI/NIR-FL Nanoprobe for "Turn-On" Imaging of β-Secretase (BACE1) Activity in Alzheimer's Disease.
2026. jún. 8.· Angewandte Chemie (International ed. in English)· PUBMED
Publikáció
FBXW7α regulates amyloid pathology by mediating ubiquitination and degradation of BACE1 in Alzheimer's disease.
2026. máj. 20.· Cell death discovery· PUBMED
Publikáció
Retraction: Repurposing food molecules as a potential BACE1 inhibitor for Alzheimer's disease.
2026. máj. 14.· Frontiers in aging neuroscience· PUBMED
Publikáció
WITHDRAWN: Molecular basis of BACE1 modulation revealed by machine learning, molecular simulations, and experimental validation.
2026. máj. 6.· International journal of biological macromolecules· PUBMED
Publikáció
NeuroBACE-ML: A reliability-aware screening framework for high-throughput prioritization of potent BACE1 inhibitors.
2026. ápr. 17.· Journal of molecular graphics & modelling· PUBMED
Publikáció
Recent advances towards BACE1 drug discovery and therapeutics design.
2026. ápr. 9.· RSC medicinal chemistry· PUBMED
Publikáció
Intranasal Formaldehyde Exposure Induces RAGE-Mediated Alteration of the ADAM10/BACE1 Expression Balance and Amyloid Deposition.
2026. márc. 30.· Biomedicines· PUBMED
Publikáció
BDNF alters β-cleavage of APP and subcellular distribution of BACE1.
2026. márc. 23.· American journal of physiology. Cell physiology· PUBMED
Publikáció
In vitro, in vivo, and in silico profiling of optimized hydrazide-hydrazone indole congeners as multi-faceted AChE, BACE1, and MAO-B inhibitors for Alzheimer's disease therapy.
2026. márc. 19.· Bioorganic chemistry· PUBMED
Publikáció
HDAC6 regulates BACE1 stability and NLRP3 inflammasome activation in Alzheimer's disease.
2026. márc. 6.· Brain : a journal of neurology· PUBMED
Publikáció
Increase in BACE1 Phosphorylation in the Rat Hippocampus and Phytosphingosine in Plasma After Chronic Administration of Scopolamine.
2026. febr. 27.· International journal of molecular sciences· PUBMED
Publikáció
In silico evaluation of bioactive compounds as potential inhibitors targeting HIF-1α/VEGFA/BACE1 pathway against Alzheimer's disease.
2026. febr. 25.· Journal of complementary & integrative medicine· PUBMED
Publikáció
Identifying Potential BACE1 Inhibitors from the ChEMBL Database Using Machine Learning and Atomistic Simulation Approaches.
2026. febr. 6.· ACS omega· PUBMED
Publikáció
Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization.
2026. febr. 1.· Aging cell· PUBMED
Publikáció
Computational prioritization of multi-target inhibitors: explainable QSAR and docking-based discovery of dual AChE/BACE1 chemotypes.
2026. jan. 28.· Journal of computer-aided molecular design· PUBMED
Publikáció
Discontinued BACE1 Inhibitors in Phase II/III Clinical Trials and AM-6494 (Preclinical) Towards Alzheimer's Disease Therapy: Repurposing Through Network Pharmacology and Molecular Docking Approach.
2026. jan. 13.· Pharmaceuticals (Basel, Switzerland)· PUBMED