Új vizsgálatok, publikációk, preprintek és pályázatok ezen a célponton, hónapról hónapra.
Publikáció
ALDH2 Suppresses Ferroptosis and Promotes Bortezomib Resistance in Multiple Myeloma Through the KEAP1-NRF2 Feedback Loop.
2026. okt. 28.· Advanced science (Weinheim, Baden-Wurttemberg, Germany)· PUBMED
Publikáció
NRF2-KEAP1 signaling in chromium-induced lung carcinogenesis: mechanistic insights and evidence gaps.
2026. okt. 22.· Toxicology mechanisms and methods· PUBMED
Publikáció
Selective NRF2 target induction despite falling NFE2L2 transcription across the MASLD spectrum: implications for marginal donor grafts and KEAP1-targeted therapy.
2026. okt. 20.· Free radical biology & medicine· PUBMED
Publikáció
Tumor-educated macrophages promote ferroptosis inhibition in pancreatic cancer via activating the p62-KEAP1-NRF2 pathway.
2026. okt. 12.· Frontiers in immunology· PUBMED
Publikáció
Variant-informed multimodal tissue-state modeling reveals an NRF2 stress niche and dependency axis in KEAP1/NFE2L2-altered cancer.
2026. okt. 6.· Frontiers in immunology· PUBMED
Publikáció
Dapagliflozin attenuates cardiomyocyte hypertrophy by inhibiting KEAP1-NRF2-mediated ferroptosis pathway.
2026. okt. 1.· The Journal of pharmacy and pharmacology· PUBMED
Publikáció
FTO mediates benzo[a]pyrene-induced lung cancer progression through regulating ferroptosis via lactylation-driven YTHDF2-KEAP1-NRF2 axis.
2026. szept. 29.· Journal of hazardous materials· PUBMED
Publikáció
Subtype-Conditioned NRF2-KEAP1 Signaling in Breast Cancer: A Narrative Review and Hypothesis-Generating Framework from Chemoprevention to Therapy Resistance.
2026. szept. 22.· Antioxidants (Basel, Switzerland)· PUBMED
Publikáció
Environmental Exposure to Triclosan Promotes Rheumatoid Arthritis via KEAP1/NRF2 Inhibition and Subsequent IL-17 Signaling Activation.
2026. szept. 22.· Environmental science & technology· PUBMED
Publikáció
KEAP1 loss-of-function suppresses immunogenic ferroptosis and limits PD-1 blockade efficacy through an NRF2-FSP1 pathway.
2026. szept. 17.· Cancer letters· PUBMED
Publikáció
The deubiquitinase YOD1 in renal tubular epithelial cells promotes diabetic kidney disease by stabilizing KEAP1.
2026. szept. 14.· Acta pharmacologica Sinica· PUBMED
Publikáció
Betulin supplementation reduces oxidative stress in Alzheimer's disease via the activation of KEAP1/NRF2 pathway.
2026. szept. 10.· The Journal of nutritional biochemistry· PUBMED
Publikáció
In situ transformable fibrillar networks ameliorate secondary brain injury after intracerebral hemorrhage by activating KEAP1-Nrf2/ARE axis.
2026. szept. 10.· Biomaterials· PUBMED
Publikáció
The Discovery of GSK3227634: A Potent Inhaled Inhibitor of the KEAP1/NRF2 Protein-Protein Interaction for the Treatment of Chronic Obstructive Pulmonary Disease.
2026. szept. 10.· Journal of medicinal chemistry· PUBMED
Publikáció
The KEAP1-NFE2L2/NRF2 Axis in Non-Small Cell Lung Cancer Radioresistance: Redox Homeostasis and Emerging DNA Damage Response Mechanisms.
2026. szept. 3.· Cancer management and research· PUBMED
Publikáció
Metformin Enhances Antioxidant Defenses and Limits Lipid Peroxidation Through the Modulation of Nrf2/KEAP1 Pathway in Hippocampal Neurons Exposed to Amyloid-β Oligomers.
2026. aug. 13.· Neurotoxicity research· PUBMED
Publikáció
ACOD1 enhances the ferroptosis resistance of tumor-associated macrophages through the KEAP1/NRF2 axis and promotes triple-negative breast cancer progression.
2026. aug. 12.· Pathology, research and practice· PUBMED
Publikáció
Case Report: DICER1-mutant primary intracranial sarcoma with concurrent TP53, PDGFRA, and KEAP1 somatic mutations in a 5.5-year-old boy.
2026. júl. 30.· Frontiers in oncology· PUBMED
Publikáció
SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.
2026. júl. 20.· Translational oncology· PUBMED
Publikáció
Hudi enteric-coated capsule and its active constituent polydatin suppress Th1/Th17-mediated intestinal inflammation by modulating the KEAP1-NFE2L2 signaling pathway.
2026. júl. 3.· Precision clinical medicine· PUBMED
Publikáció
Clinical Outcomes Associated with Single STK11 Mutations and Those Co-occurring with KEAP1 and KRAS Mutations in Metastatic Non-Small Cell Lung Cancer.
2026. jún. 30.· Advances in therapy· PUBMED
Publikáció
Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy.
2026. jún. 16.· Antioxidants (Basel, Switzerland)· PUBMED
Publikáció
Regulation of the KEAP1/NRF2 pathway by claudin-2-targeted lymphoid enhancer-binding factor 1 binding in gastric cancer progression.
2026. jún. 10.· Journal of physiology and pharmacology : an official journal of the Polish Physiological Society· PUBMED
Preprint
SMARCA4, STK11, and KEAP1 co-inactivation associates with poor prognosis and upregulation of the TGF-β pathway in lung adenocarcinoma.
2026. jún. 8.· bioRxiv : the preprint server for biology· PUBMED
Publikáció
CUL7-mediated KEAP1 ubiquitination promotes the progression of colon cancer via NRF2 signaling.
2026. jún. 8.· Cell death & disease· PUBMED
Publikáció
KEAP1 promoter hypermethylation in human cancers: a meta-analysis of case-control studies.
2026. jún. 6.· International journal of clinical oncology· PUBMED
Publikáció
TSC22D4 drives clear cell renal cell carcinoma progression and therapy resistance by stabilizing NRF2 through KEAP1 disruption.
2026. jún. 5.· Cell death & disease· PUBMED
Publikáció
PEBP4 alleviates muscle wasting in lung cancer cachexia via KEAP1-NRF2-mediated redox homeostasis.
2026. jún. 3.· Cell death & disease· PUBMED
Publikáció
Corrigendum to "KRAS G12C inhibitor outcomes in advanced non-small cell lung cancer by smoking history, performance status, and KEAP1 mutation status" [Cancer Treatment and Research Communications 47 (2026) 101227].
2026. máj. 16.· Cancer treatment and research communications· PUBMED
Publikáció
KEAP1-mediated mitochondrial remodeling on stiffness-graded collagen substrates drives hepatocellular carcinoma adaptation.
2026. máj. 12.· Biomaterials· PUBMED