Új vizsgálatok, publikációk, preprintek és pályázatok ezen a célponton, hónapról hónapra.
Vizsgálat
A Vaccine (STEMVAC) for Improving Survival in Patients With Triple-Negative Breast Cancer and Moderate or Extensive Residual Cancer Burden
2026. nov. 1.· PHASE2 · NOT_YET_RECRUITING· CTGOV
Publikáció
The influence of LINC00511 and MDM2/MDM4 in lung carcinoma: Implications for immunological therapeutic strategies.
2026. nov. 1.· Pakistan journal of pharmaceutical sciences· PUBMED
Publikáció
Correction: Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype.
2026. okt. 26.· PloS one· PUBMED
Publikáció
Integrating AI-Based De Novo Design with Molecular Docking and Density Functional Theory Analysis to Optimize Flavonoid Scaffolds as p53-MDM2 Inhibitors for Triple-Negative Breast Cancer.
2026. okt. 26.· Current topics in medicinal chemistry· PUBMED
Publikáció
Yindan Xinnaotong Soft Capsule Ameliorates Parkinson's Disease and is Associated with Modulation of the AKT/MDM2/p53 Pathway: Network Pharmacology, Molecular Docking, and Experimental Validation.
2026. okt. 22.· CNS & neurological disorders drug targets· PUBMED
Publikáció
Case Report WIN-MTB-2024001 - WIN International Molecular Tumor Board: A 55-year-old male with glioblastoma exhibiting amplifications in MDM2 and EGFR.
2026. okt. 16.· Oncotarget· PUBMED
Publikáció
Intimal sarcoma of the pulmonary vein with left atrial extension: a case report and diagnostic relevance of MDM2.
2026. okt. 15.· Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia· PUBMED
Publikáció
KT-253, a highly potent and selective MDM2 protein degrader, eliminates malignant myelofibrosis stem/progenitor cells.
2026. okt. 6.· Leukemia· PUBMED
Publikáció
A Self-Assembled Affibody-Drug Conjugate Nanoagent for EGFR-Targeted Synergistic Codelivery of Exatecan and an MDM2 Inhibitory Peptide.
2026. okt. 5.· Molecular pharmaceutics· PUBMED
Publikáció
Strategies for Overcoming Acquired Resistance of Tumor Cells to MDM2 Inhibitors.
2026. okt. 1.· Biochemistry. Biokhimiia· PUBMED
Publikáció
A membrane-penetrating modified ascites-derived peptide, TAT-CPAP1, sensitizes TP53 wild-type ovarian cancer cells to platinum-based therapy through targeting the NOLC1-MDM2/MDM4 axis.
2026. okt. 1.· Translational oncology· PUBMED
Publikáció
S100A1 Promotes MDM2-Mediated KLF15 Ubiquitination to Regulate ID1-Driven Tubular Injury in Diabetic Kidney Disease.
2026. szept. 30.· FASEB journal : official publication of the Federation of American Societies for Experimental Biology· PUBMED
Publikáció
Correction: Resveratrol targeting MDM2/P53/PUMA axis to inhibit colonocyte apoptosis in DSS-induced ulcerative colitis mice.
2026. szept. 25.· Frontiers in pharmacology· PUBMED
Publikáció
[Retracted] CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells.
2026. szept. 25.· Molecular medicine reports· PUBMED
Publikáció
E3 Ubiquitin Ligase MDM2 Contributes to Proliferation, Migration/Invasion, Epithelial-Mesenchymal Transition, and Glycolytic Reprogramming in Lung Cancer via Ubiquitinating and Degrading MYH11 Protein.
2026. aug. 31.· Molecular carcinogenesis· PUBMED
Publikáció
Driver genomic lesions in MDM2, CDK4, and JUN co-opt targetable super-enhancer networks to impose liposarcomagenic core regulatory circuitry.
2026. aug. 31.· Journal of advanced research· PUBMED
Publikáció
Computational screening of natural product inhibitor stargeting the MDM2-p53 interaction: docking and molecular dynamics insights for retinoblastoma therapy.
2026. aug. 15.· American journal of translational research· PUBMED
Publikáció
A First-in-Pediatric Study of ALRN-6924, a Novel Stapled-Peptide Dual MDM2/MDMX Inhibitor, for Children with Advanced Hematologic and Solid Malignancies.
2026. aug. 14.· Clinical cancer research : an official journal of the American Association for Cancer Research· PUBMED
Publikáció
Retraction Note: Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells.
2026. aug. 12.· Scientific reports· PUBMED
Publikáció
Dual MDM2 and PPARG regulatory axes mediate the antiepileptic effects of Gouteng: An integration of bioinformatics, network pharmacology, machine learning, molecular docking, and MD simulations.
2026. aug. 10.· Neuropharmacology· PUBMED
Publikáció
MYC-driven BYSL overexpression promotes hepatocellular carcinoma by suppressing nucleolar stress and inactivating the RPL5/RPL11-MDM2-p53 pathway.
2026. aug. 10.· Cellular signalling· PUBMED
Publikáció
MDM2 deletion and its associated p53 activation in subcutaneous white adipose tissue induce hepatic fibrosis via galectin-3 in a mouse model.
2026. aug. 7.· Metabolism: clinical and experimental· PUBMED
Publikáció
Droplet Digital PCR Assessment of MDM2 Amplification in Liposarcoma Diagnosis and Prognosis: A French Single-Center Cohort Study.
2026. aug. 2.· International journal of molecular sciences· PUBMED
Publikáció
Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers.
2026. aug. 1.· Cell death & disease· PUBMED
Publikáció
LncDNAH5 Regulates Radiation Therapy-Induced Toxicity via MDM2-Mediated Degradation of TP53BP1.
2026. aug. 1.· International journal of radiation oncology, biology, physics· PUBMED
Publikáció
Activating Sigma1R by fluoxetine suppresses neuronal ferroptosis in epilepsy by inhibiting MDM2-mediated GPX4 ubiquitination.
2026. aug. 1.· Journal of advanced research· PUBMED
Publikáció
E3 Ubiquitin Ligase MDM2 Promotes Growth and CD8+ T Cell Dysfunction in Gastric Cancer Through Degradation of SST.
2026. júl. 31.· Journal of gastroenterology and hepatology· PUBMED
Publikáció
Routine MDM2 FISH Testing and Preoperative Biopsy Reduces Recurrence Rate of Atypical Lipomatous Tumours.
2026. júl. 29.· Journal of surgical oncology· PUBMED
Publikáció
hsa_circ_0008758 Activates the MDM2/FOXO3a/PGK1 Pathway Through the miR-361-3p/SPIN1 Axis to Promote the Warburg Effect of Non-Small Cell Lung Cancer.
2026. júl. 22.· Tissue engineering and regenerative medicine· PUBMED
Publikáció
Transcriptomic Stratification Reveals an FRS2-Associated, Proliferation-Independent Phenotype in MDM2-High Sarcomas.
2026. júl. 22.· Current oncology (Toronto, Ont.)· PUBMED