SNCA

Betegségek

• Parkinson disease13 vizsgálat
• Lewy body dementia3 vizsgálat

Az elmúlt 24 hónap

Új vizsgálatok, publikációk, preprintek és pályázatok ezen a célponton, hónapról hónapra.

VizsgálatokPublikációkPreprintekPályázatok

• Publikáció

  Molecular determinants of α-synuclein toxicity and aggregation revealed by deep mutagenesis.

  2026. nov. 25.· Biochemical Society transactions· PUBMED

• Publikáció

  New hemiaminal ether dihydropyrimidinones as CK1/CK2 inhibitors targeting α-synuclein in Parkinson's disease.

  2026. nov. 2.· RSC advances· PUBMED

• Publikáció

  Protein adduction by multiple aldehydes contributes to α-synuclein aggregation and dopaminergic neuron loss in rat models of Parkinson's disease.

  2026. nov. 2.· Redox biology· PUBMED

• Publikáció

  Iron affects association and dissociation rates of α-synuclein iron-responsive element mRNA binding to iron regulatory protein in Parkinson's disease.

  2026. okt. 31.· International journal of biological macromolecules· PUBMED

• Publikáció

  Distinct mitochondrial states modulate α-synuclein toxicity.

  2026. okt. 26.· Molecular biology of the cell· PUBMED

• Preprint

  Cerebrospinal fluid α-synuclein seed amplification assay positivity identifies a prognostically distinct subgroup in amyotrophic lateral sclerosis.

  2026. okt. 26.· medRxiv : the preprint server for health sciences· PUBMED

• Publikáció

  Serratol, a cembrane diterpene from Boswellia serrata attenuates α-synuclein and fibrillar amyloid-β aggregation in Caenorhabditis elegans.

  2026. okt. 23.· Journal of ethnopharmacology· PUBMED

• Publikáció

  High-altitude environments elevate central and peripheral α-synuclein levels and accelerate PD-related pathology.

  2026. okt. 21.· Journal of translational medicine· PUBMED

• Publikáció

  Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in Parkinson's disease.

  2026. okt. 20.· The Journal of experimental medicine· PUBMED

• Publikáció

  Discovery of benzoxazole derivatives as novel α-synuclein aggregate ligands with potential for PET tracer development.

  2026. okt. 20.· European journal of medicinal chemistry· PUBMED

• Publikáció

  The morphology of α-synuclein fibrils changes during formation, storage, and upon exposure to ligands.

  2026. okt. 19.· Organic & biomolecular chemistry· PUBMED

• Publikáció

  Disarming CH25H to clear α-synuclein.

  2026. okt. 14.· Trends in molecular medicine· PUBMED

• Publikáció

  Modulators selectively reshape α-synuclein phase transitions.

  2026. okt. 14.· The Journal of chemical physics· PUBMED

• Publikáció

  Extracellular vesicle α-synuclein topology reveals disease-associated conformers in brain and blood.

  2026. okt. 14.· Brain : a journal of neurology· PUBMED

• Publikáció

  Severe Parkinson's Disease Linked to SNCA Locus Triplication Is Associated with Expression Changes in Platelets: A Case Report.

  2026. okt. 14.· Movement disorders : official journal of the Movement Disorder Society· PUBMED

• Publikáció

  Elevated erythrocyte membrane pS42-α-synuclein in Parkinson's disease and its changes following plasma cross-incubation.

  2026. okt. 14.· Parkinsonism & related disorders· PUBMED

• Publikáció

  Dibucaine induces autophagic flux and reduces Ser129-phosphorylated α-synuclein in induced pluripotent stem cell-derived neurons with SNCA duplication.

  2026. okt. 8.· Frontiers in neurology· PUBMED

• Publikáció

  Human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis.

  2026. okt. 7.· Science translational medicine· PUBMED

• Publikáció

  Amyloid, p-tau, neurofilament light, and α-synuclein cerebrospinal fluid biomarkers across Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease.

  2026. okt. 6.· Alzheimer's & dementia (Amsterdam, Netherlands)· PUBMED

• Publikáció

  Clinical and biomarker predictors of α-synuclein seeding in cognitive impairment and motor parkinsonism.

  2026. okt. 4.· Parkinsonism & related disorders· PUBMED

• Publikáció

  Astrocytic cathepsin D promotes α-synuclein processing and Lewy neurite-like aggregate maturation.

  2026. okt. 2.· EMBO reports· PUBMED

• Vizsgálat

  Prevent Cognitive Decline in GBA-associated Parkinson's Disease

  2026. okt. 1.· PHASE2 · RECRUITING· CTGOV

• Publikáció

  α-synuclein pathology drives region-specific tau deposition.

  2026. okt. 1.· Alzheimer's & dementia : the journal of the Alzheimer's Association· PUBMED

• Publikáció

  Full-length brain-derived α-synuclein fibril models reveal fuzzy-coat control of peptide recognition.

  2026. okt. 1.· Protein science : a publication of the Protein Society· PUBMED

• Publikáció

  Visualizing α-synuclein pathology in live brain: A new platform for Parkinson's disease research.

  2026. okt. 1.· Clinical and translational medicine· PUBMED

• Publikáció

  High-resolution genomic architecture of a 1.71-Mb inverted SNCA triplication in a patient-derived PARK4 model.

  2026. szept. 30.· Biochemical and biophysical research communications· PUBMED

• Publikáció

  Crosstalk between exosomes and cellular senescence: A core vicious loop promoting α-synuclein pathology in Parkinson's disease.

  2026. szept. 30.· Neural regeneration research· PUBMED

• Publikáció

  Condensate-driven triglyceride reduction links α-synuclein to mitochondrial dysfunction.

  2026. szept. 29.· EMBO reports· PUBMED

• Publikáció

  Targeting CH25H restores p62-mediated α-synuclein clearance.

  2026. szept. 28.· Trends in pharmacological sciences· PUBMED

• Publikáció

  Sephin1 directly targets PHB2 to activate PINK1-PRKN-dependent mitophagy and alleviate α-synuclein neurotoxicity in Parkinson's disease models.

  2026. szept. 25.· Biochemical pharmacology· PUBMED

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