MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE
Key facts
- Where
- Esbjerg, DániaSee the site
- Phase
- 2. fázis
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 64 years old?
Where in Dánia
- Sydvestjysk SygehusEsbjerg, DániaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sydvestjysk Sygehus
- Trial code
- EU 2022-500779-29-00
- Record updated
- 2025. december 16.
- Original description
It is expected that the trial will produce important knowledge on the safety and efficacy of morphine for perioperative pain, which will be beneficial for future surgical patients, in particular for bariatric patients suffering from obstructive sleep apnoea subjected to bariatric surgery.Read full original descriptionShow less
MORPHINE PHARMACOKINETICS AND –DYNAMICS IN HEALTHY VOLUNTEERS AND PATIENTS WITH OBESITY AND OBSTRUCTIVE SLEEP APNOEA. -AN INVESTIGATOR INITIATED, CLINICAL STUDY OF THE IMPACT OF OBESITY AND SLEEP APNOEA ON THE PHARMACOLOGY OF MORPHINE
It is expected that the trial will produce important knowledge on the safety and efficacy of morphine for perioperative pain, which will be beneficial for future surgical patients, in particular for bariatric patients suffering from obstructive sleep apnoea subjected to bariatric surgery.
Furthermore, we aim to gain from new insights and understanding of the pharmacokinetics and pharmacodynamics of morphine – which to this day is a first line drug when acute pain-relief is needed. We aim to further our knowledge and understanding of a more personalized approach to the treatment of acute peri- and postoperative pain, i.e. delivering sufficient pain-relief with an absolute minimum of side effects.
Inclusion: Obesity; Obstructive sleep apnoea.
Exclusion: Known allergy towards morphine; Severe heart failure; History of substance abuse; History of mayor psychiatric illness; Severe acute respiratory affection, i.e. airway infections; Known history of severe chronic pain; Female participants that are breastfeeding; Intake of alcohol within 24 hours before start of the trial; Inability to present a negative pregnancy test; Increased intracranial pressure; Severe decreased renal or hepatic function; Severe COPD or asthma.