Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients
Key facts
- Where
- Hellerup, DániaSee the site
- Phase
- 2. fázis
Where in Dánia
- Gentofte HospitalHellerup, DániaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Gentofte Hospital
- Trial code
- EU 2023-504519-34-01
- Record updated
- 2024. április 23.
- Original description
To characterize the changes in the innate immune system of COPD patients upon vaccination with live vaccines and determine if vaccination induces trained immunity as reported previously in other populations.Read full original descriptionShow less
Using live vaccines to induce beneficial innate immune training and reduce systemic inflammation in COPD patients (COPD-LIVE)
To characterize the changes in the innate immune system of COPD patients upon vaccination with live vaccines and determine if vaccination induces trained immunity as reported previously in other populations.
Inclusion: Must have specialist verified, spirometry-confirmed, COPD; Age > 40 years; Able to give informed consent.
Exclusion: Oral or intravenous corticosteroid at a dose ≥10 mg/day over 3 months; Known allergy to either the BCG or MMR vaccines or severe adverse effects during prior vaccination; Known prior, active or latent infection with mycobacterium tuberculosis; Vaccination with a live vaccine within 4 weeks; Cardiac arythmia; Allergy to MMR vaccine components, neomycin or egg proteins; Severe immunocompromisation (HIV-1 infection, organ- or bone marrow transplantation, chemotherapy, primary immune defect, anti-cytokine therapy, immunosuppressant treatment); Active solid or non-solid malignancy or lymphona within 2 years, excluding basal cell carcinoma; Acute febrile ilness; Blood dyscrasia; Pregnancy or breastfeeding.