General anesthesia versus sedation with high-flow nasal cannula for the endovascular treatment of acute ischemic stroke
Key facts
- Where
- Madrid, SpanyolországSee the site
- Phase
- 4. fázis
Where in Spanyolország
- Hospital Universitario La PazMadrid, SpanyolországTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospital Universitario La Paz
- Trial code
- EU 2024-510752-12-00
- Record updated
- 2024. szeptember 10.
- Original description
The primary objective of the study is to assess the time from hospital arrival to revascularization in patients with acute ischemic stroke treated with mechanical thrombectomy, depending on whether the procedure was performed under sedation with HFNC or under general anesthesia.Read full original descriptionShow less
General anesthesia versus sedation with high-flow nasal cannula for the endovascular treatment of acute ischemic stroke. GHIFTS Study (General anesthesia vs High Flow nasal cannula for Thrombectomy on Stroke)
The primary objective of the study is to assess the time from hospital arrival to revascularization in patients with acute ischemic stroke treated with mechanical thrombectomy, depending on whether the procedure was performed under sedation with HFNC or under general anesthesia.
Inclusion: Age greater than or equal to 18 years; NIHSS ≥ 6 and ≤ 25; Anterior circulation stroke with isolated or combined occlusion of: - Intracranial Internal Carotid Artery. - Middle Cerebral Artery in its M1 or M2 segments; Time of evolution from clinical onset to radiology ward admission < 6 hours, or < 24 hours since last seen asymptomatic if salvageable tissue is demonstrated on neuroimaging tests; Informed consent signed by the patient if capable, or by a family member/legal representative if the patient is not capable.
Exclusion: Recent maxillofacial trauma/surgery; Failure to comply with fasting (6 hours of solids and 2 hours of clear liquids); Allergy or intolerance to any of the medications used for sedation or general anesthesia; Acute cerebral hemorrhage or clear hemorrhagic transformation in the same vascular territory; Coma on admission (Glasgow Coma Scale < 8); Baseline severe dependency status (mRS>3); Severe/significant agitation on admission; Objective loss of airway protection reflexes or vomiting on admission; Known or suspected difficult airway on examination; Thrombopenia <50,000 or severe coagulation disturbances.