Early detection of hepatocellular carcinoma by Hyperpolarized [1- 13C]pyruvate MRI
Key facts
- Where
- Aarhus N, DániaSee the site
- Phase
- 2. fázis
Where in Dánia
- Aarhus UniversitetshospitalAarhus N, DániaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aarhus Universitet
- Trial code
- EU 2024-512490-27-00
- Record updated
- 2026. augusztus 29.
- Original description
This project seeks to determine the potential of hyperpolarized pyruvate MRI in early characterization of primary liver cancer - particularly small tumors.Read full original descriptionShow less
This project seeks to determine the potential of hyperpolarized pyruvate MRI in early characterization of primary liver cancer - particularly small tumors.
Inclusion: Aged 18 – 85 years. The age and gender of the healthy controls of the main study will be matched to the participating patients; Pre-menopausal women must be confirmed non-pregnant by an onsite test; HCC group: - Diagnosed HCC larger than 10 mm confirmed by standard MRI, CT or confirmed by tumour biopsy. - Subgroup 1: Not elected for liver surgery - Subgroup 2: Elected for liver surgery; Small tumor group: - One or more small lesions in the liver requiring 2 years of repeated follow-up as per the EASL guideline. Could be in a liver with a confirmed HCC.
Exclusion: Pacemaker, neurostimulator or cholera implant; Chronic kidney disease; Competing systemic disease (hypertension, dyslipidemia, diabetes etc. allowed); Allergy to pyruvate; Significant cardiac disease (as left ventricular outflow obstruction or heart failure); Significant obstructive lung disease or severe asthma; Unsafe medical implants (safety of heart valves, hips and the like must be confirmed); Patients with tumors must have eGFR > 30 ml/min/1.73m2; Contraindications for MRI with contrast:; Hepatic encephalopathy ≥ grade 2; Stents or other devices implanted close to the liver that may cause imaging artefacts; Metal foreign bodies such as fragments and irremovable piercings; Largest circumference including arms > 160 cm; Claustrophobia.