Chronic kidney disease – imaging the metabolic derangements with ultra-sensitive MRI
Key facts
- Where
- Aarhus N, DániaSee the site
- Phase
- 2. fázis
Where in Dánia
- Aarhus UniversitetAarhus N, DániaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aarhus Universitet
- Trial code
- EU 2024-512491-35-00
- Record updated
- 2026. június 3.
- Original description
In this study, we aim to assess the metabolic signature of CKD and PDK using multi-parametric MRI. The study will include healthy volunteers (N=8), CKD patients (N=12), PKD patients (N=10). PDK patients: a. The metabolic shift towards glycolysis compared with healthy kidneys can be detected using MRI with hyperpolarized pyruvate.Read full original descriptionShow less
In this study, we aim to assess the metabolic signature of CKD and PDK using multi-parametric MRI. The study will include healthy volunteers (N=8), CKD patients (N=12), PKD patients (N=10). PDK patients: a. The metabolic shift towards glycolysis compared with healthy kidneys can be detected using MRI with hyperpolarized pyruvate.
CKD patients a. Multi-parametric MRI combined with hyperpolarized pyruvate MRI can detect the metabolic alterations, including upregulated lactate and alanine production, associated with CKD. b. These alterations correlate with measures of fibrosis and inflammation from biopsies
Inclusion: Aged 18 – 85 years (all participants); Pre-menopausal women must be confirmed non-pregnant by an onsite test. (All female participants); Autosomal dominant polycystic kidney disease. (PKD group); CKD for any reason except PKD. (CKD group); Recent biopsy (within 6 months of MRI). (CKD group); eGFR > 60 (PKD patients).
Exclusion: Contraindications for MRI: - Significant cardiac disease such as severe left ventricular outflow obstruction - Significant obstructive lung disease or severe asthma - Pacemaker, neurostimulator or cholera implant - Metal foreign bodies such as fragments and irremovable piercings - Unsafe medical implants (safety of heart valves, hips and the like must be confirmed) - Claustrophobia - Largest circumference including arms > 160 cm; Competing renal or systemic disease (except unspecific renal MRI findings, hypertension, atherosclerosis, well-regulated diabetes and hyperlipidemia/cholesterolemia which are allowed); Renovascular disease; Allergy to pyruvate.