Phase II, multicenter, open-label, randomized, controlled, open-label clinical trial to eliminate the latent reservoir of HIV-1 by administration of high doses of antiretroviral drugs.
Key facts
- Where
- Madrid, SpanyolországSee the 2 sites
- Phase
- 2. fázis
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 64 years old?
Where in Spanyolország
- Hospital Universitario 12 de OctubreMadrid, SpanyolországNo longer taking part
- Ramón y Cajal University HospitalMadrid, SpanyolországNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundacion Para La Investigacion Biomedica Del Hospital Universitario Ramon Y Cajal
- Trial code
- EU 2024-513366-18-00
- Record updated
- 2026. április 10.
- Original description
To evaluate the variation in the size of the latent cellular reservoir of HIV-1 after reaching inhibitory tissue concentrations by administration of high doses of antiretroviral drugs.Read full original descriptionShow less
To evaluate the variation in the size of the latent cellular reservoir of HIV-1 after reaching inhibitory tissue concentrations by administration of high doses of antiretroviral drugs.
Inclusion: Undetectable plasma viral load (<50 copies of HIV RNA in blood plasma) for at least 12 months prior to inclusion. ● Antiretroviral treatment with a triple regimen containing an integrase inhibitor. ● R5 viral tropism, determined in proviral DNA.
Exclusion: Chronic Hepatitis B (HBsAg +) - Untreated chronic hepatitis C - Viral tropism X4; Impaired renal function (plasma creatinine >1.5 mg/dl, creatinine clearance <60 ml/min/1.73 m2); Concomitant treatment with cytochrome CYP3A inducing or inhibiting drugs.