GLUTAMICS III
Key facts
- Where
- Goteborg, Linkoping, Lund, Orebro és Uppsala, SvédországSee the 5 sites
- Phase
- 3. fázis
Where in Svédország
- Sahlgrenska University Hospital-Vaestra GoetalandsregionenGoteborg, SvédországToborzás még nem indult
- Region OestergoetlandLinkoping, SvédországToborzás még nem indult
- Region Skane Skanes UniversitetssjukhusLund, SvédországToborzás még nem indult
- Region Oerebro LaenOrebro, SvédországToborzás még nem indult
- Uppsala University HospitalUppsala, SvédországToborzás még nem indult
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Region Oestergoetland
- Trial code
- EU 2024-513575-40-01
- Record updated
- 2026. június 4.
- Original description
To establish the efficacy of intravenous glutamate infusion to prevent acute kidney injury (AKI) after coronary artery bypass surgery (CABG) among high-risk patients without diabetes.Read full original descriptionShow less
Glutamate infusion for prevention of Acute Kidney Injury in surgery for ischemic heart disease: (GLUTAMICS III = GLUTAmate for Metabolic Intervention in Coronary Surgery III)
To establish the efficacy of intravenous glutamate infusion to prevent acute kidney injury (AKI) after coronary artery bypass surgery (CABG) among high-risk patients without diabetes.
Inclusion: Adult patients without diabetes operated on heart-lung machine with CABG of at least two vessel disease or left main stenosis with or without a concomitant procedure and who either have EuroSCORE II ≥ 3.0 to which at least one cardiac or procedure related risk factor contribute or Left Ventricular Ejection Fraction ≤ 0.30 regardless of EuroSCORE II.
Exclusion: Diabetes; ambiguous food allergy known to have elicited flushing, headache, rash or asthma; age > 85 years; previous cardiac surgery; informed consent not possible because of critical condition or other reason; preoperative use of inotropic support or mechanical circulatory assist; preoperative dialysis or calculated Creatinine clearance < 30 mL/min; surgery without heart-lung machine (off-pump); concomitant Maze-procedure; surgery of ascending aorta necessitating circulatory arrest; surgery of both aortic and mitral valve.