Low dose cisplatin weekly versus high dose cisplatin every three weeks in primary chemoradiation in sarcopenic head and neck cancer patients
Key facts
- Where
- Alkmaar, Amsterdam, Leiden és Utrecht, HollandiaSee the 5 sites
- Phase
- 4. fázis
Where in Hollandia
- Noordwest Ziekenhuisgroep StichtingAlkmaar, HollandiaNo longer taking part
- Amsterdam UMC StichtingAmsterdam, HollandiaNo longer taking part
- Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis StichtingAmsterdam, HollandiaNo longer taking part
- Leids Universitair Medisch Centrum (LUMC)Leiden, HollandiaNo longer taking part
- Universitair Medisch Centrum UtrechtUtrecht, HollandiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universitair Medisch Centrum Utrecht
- Trial code
- EU 2024-514919-10-00
- Record updated
- 2024. november 11.
- Original description
To investigate if the use of weekly low dose cisplatin increases compliance to the planned chemotherapy scheme in LA-HNSCC patients with low SMM to a level of compliance to three-weekly high dose cisplatin of patients without low SMM.Read full original descriptionShow less
Low dose cisplatin weekly versus high dose cisplatin every three weeks in primary chemoradiation in sarcopenic patients with head and neck squamous cell carcinoma
To investigate if the use of weekly low dose cisplatin increases compliance to the planned chemotherapy scheme in LA-HNSCC patients with low SMM to a level of compliance to three-weekly high dose cisplatin of patients without low SMM.
Inclusion: considered, eligible and planned for primary cisplatin CRT by treating physician; - eighteen years of age or older; - sufficient understanding of Dutch and medical consequences to give informed consent.
Exclusion: mentally disabled or patients with significantly altered mental status that would prohibit understanding and giving informed consent; - a history of bilateral lymph node dissection in the neck and no available (PET-)CT scan of the third lumbar vertebra; - an absolute contraindication for cisplatin as defined by the treating physician, including relevant pre-existing kidney insufficiency, clinically apparent vascular disease (for example claudicatio intermittens), clinically relevant perceptive deafness, serious neuropathy and poor performance score.