HOPE study
Key facts
- Where
- Alicante, Barakaldo, Barcelona, Girona, Murcia, Oviedo, Salamanca, Santiago de Compostela, Sevilla, Tarragona, Valencia és Zaragoza, SpanyolországSee the 15 sites
- Phase
- 4. fázis
Where in Spanyolország
- Complexo Hospitalario Universitario A Coruña (La Coruña, Spain)SpanyolországNo longer taking part
- Hospital General Universitario Dr. BalmisAlicante, SpanyolországNo longer taking part
- Hospital Universitario de CrucesBarakaldo, SpanyolországNo longer taking part
- Hospital de la Santa Creu i Sant PauBarcelona, SpanyolországNo longer taking part
- Hospital del MarBarcelona, SpanyolországNo longer taking part
- Hospital Universitari de Girona Doctor Josep TruetaGirona, SpanyolországNo longer taking part
- University Clinical Hospital Virgen De La ArrixacaMurcia, SpanyolországNo longer taking part
- Hospital Universitario Central De AsturiasOviedo, SpanyolországNo longer taking part
- Hospital Universitario De SalamancaSalamanca, SpanyolországNo longer taking part
- Complexo Hospitalario Universitario De SantiagoSantiago de Compostela, SpanyolországNo longer taking part
- University Hospital Virgen Del Rocio S.L.Sevilla, SpanyolországNo longer taking part
- Hospital Universitari Joan XXIII de TarragonaTarragona, SpanyolországNo longer taking part
- Hospital Clinico Universitario de ValenciaValencia, SpanyolországNo longer taking part
- Hospital Universitario Y Politecnico La FeValencia, SpanyolországNo longer taking part
- Hospital Universitario Miguel ServetZaragoza, SpanyolországNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau
- Trial code
- EU 2024-516642-19-01
- Record updated
- 2025. július 7.
- Original description
Compare the clinical benefit of standard blood pressure management after mechanical thrombectomy versus a specific protocol aimed at hemodynamic optimization, where blood pressure targets are applied based on the degree of recanalization achieved during the procedure.Read full original descriptionShow less
A randomized trial on Hemodynamic Optimization of cerebral Perfusion after Endovascular therapy in patients with acute ischemic stroke (HOPE study)
Compare the clinical benefit of standard blood pressure management after mechanical thrombectomy versus a specific protocol aimed at hemodynamic optimization, where blood pressure targets are applied based on the degree of recanalization achieved during the procedure.
Compare the clinical benefit of standard blood pressure management after mechanical thrombectomy versus a specific protocol aimed at hemodynamic optimization, where blood pressure targets are applied based on the degree of recanalization achieved during the procedure.
Inclusion: Patients with acute ischemic stroke and large intracranial vessel occlusion within 24 hours of symptom onset who have undergone mechanical thrombectomy; Successful recanalization, defined as a TICI score of 2b, 2c, or 3; Prior score on the modified Rankin Scale (mRS) of 0, 1, or 2; The patient or their legal representative provides informed consent in writing or verbally.
Exclusion: Use of MAO inhibitors; History of intracerebral hemorrhage; Patient with congestive heart failure or unstable or recent coronary artery disease (<3 months); Any visible hemorrhage on the initial CT scan; History of ventricular arrhythmias; ASPECTS score < 6; Inclusion in other clinical trials; Occlusion in the vertebral, basilar, A2, P2, and M3-4 arteries; Pregnant or lactating patient; Dissection of the aorta, cervical, or cerebral arteries, or unruptured aortic/cerebral aneurysm or known arteriovenous malformation.