[68Ga]FAPI PET/CT to detect fibroblast activity in pulmonary COVID patients with and without long-term health problems.
Key facts
- Where
- Groningen, HollandiaSee the site
- Phase
- 4. fázis
Where in Hollandia
- University Medical Center GroningenGroningen, HollandiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universitair Medisch Centrum Groningen
- Trial code
- EU 2024-517931-29-00
- Record updated
- 2025. szeptember 22.
- Original description
To assess if pulmonary fibroblast activity, measured by [68Ga]FAPI-PET/CT, is higher in patients with current long COVID dyspnea and fatigue compared to patients with resolved complaints.Read full original descriptionShow less
LIBERATE; From Inflammation Biomarkers to Remodelling (FAPI PET/CT) towards personalized diagnosis in post-acute sequelae of COVID-19
To assess if pulmonary fibroblast activity, measured by [68Ga]FAPI-PET/CT, is higher in patients with current long COVID dyspnea and fatigue compared to patients with resolved complaints.
Inclusion: Adult patients > 20 years; Self-reported complaints of dyspnea or fatigue > 3 months after SARS-CoV-2 infection confirmed with PCR, serology test or COVID-19 Reporting and Data System (CO-RADS) score 4/5; Group 1: Fatigue Severity Scale ≥ 4 at time of [68Ga]FAPI PET/CT; Group 2: Fatigue Severity Scale < 4 at time of [68Ga]FAPI PET/CT after having previously recorded score of ≥ 4 or equivalent; In addition, when insufficient when insufficient subjects can be included in group 2 ‘Healthy’ controls will be included from the Lifelines or PARASOL cohort with the following criteria: Patients without self-reported complaints and past SARS-CoV-2 infection (which would have resulted in a Fatigue Severity Scale < 4) or without experienced confirmed SARS-CoV-2 infection.
Exclusion: History of claustrophobia or feeling of inability to tolerate supine position for the PET/CT scans; Inability or unwilling to give informed consent.