Taking people in Ausztria4. fázis
Pulmonary pharmacokinetics of piperacillin/tazobactam and levofloxacin in patients with chronic obstructive pulmonary disease or cystic fibrosis: Comparison of epithelial lining fluid, in-vivo microdialysis and tissue biopsy. An exploratory pharmacokinetic study.
Key facts
- Where
- Vienna, AusztriaSee the site
- Phase
- 4. fázis
Where in Ausztria
- Medical University of ViennaVienna, AusztriaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medical University Of Vienna
- Trial code
- EU 2024-518337-29-00
- Record updated
- 2024. december 11.
- Original description
The primary objective is the head-to-head comparison of three methods for measuring pulmonary antibiotic pharmacokinetics. Epithelial lining fluid concentrations at 75', tissue biopsy concentrations at 75' and in-vivo microdialysis concentrations during the 60-90' interval will be compared.Read full original descriptionShow less
The primary objective is the head-to-head comparison of three methods for measuring pulmonary antibiotic pharmacokinetics. Epithelial lining fluid concentrations at 75', tissue biopsy concentrations at 75' and in-vivo microdialysis concentrations during the 60-90' interval will be compared.
Inclusion: Written informed consent; Planned bilateral lung transplantation; Diagnosis of COPD or CF; Age: > 18 and < 90 years.
Exclusion: Prior lung transplantation; Known allergy to study drugs; Preoperative renal failure; Chronic severe renal insufficiency including haemodialysis; Chronic severe liver disease; Inability to give informed consent; ECLS bridging.