A randomized phase III trial of short-course versus long-course pre-operative chemotherapy with mFOLFIRINOX or PAXG regimen for stage I-III pancreatic ductal adenocarcinoma (PDAC)

Trial details

Who runs it

Associazione Italiana Per Lo Studio Del Pancreas

Trial code

EU 2024-519031-42-00

Record updated

2026. június 16.

Original description

to compare in terms of EFS the efficacy of PAXG to that of mFOLFIRINOXRead full original descriptionShow less

to compare in terms of EFS the efficacy of PAXG to that of mFOLFIRINOX

Inclusion: Cyto/histological diagnosis of pancreatic ductal adenocarcinoma; Women must not be on pregnancy or lactation; Patient of child-bearing potential must agree to use two medically acceptable methods of contraception (one for the patient and one for the partner) during the study and for a minimum of the following 6 months; this applies to patients of both sexes. [appendix 4]; Patient information and signed written informed consent; Clinical stage I-III disease according to TNM 8th Ed. 2017 [appendix 1]; Resectable or borderline resectable disease, as anatomically defined according to NCCN Guidelines Version 1.2020 – Pancreatic Adenocarcinoma [appendix 2] and biologically defined according to the International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017 (CA 19.9 > 500 IU/ml) (Isaji et al., 2018); Karnofsky Performance Status > 60%; Age  18 and ≤ 75 years; Adequate bone marrow function (GB ≥ 3500/mm3, neutrophils ≥1500/mm3, platelets ≥ 100000/mm3, Hb ≥10 g/dl); Adequate kidney function (serum creatinine < 1.5 mg/dL); Adequate liver function: - ALT and AST < 3 ULN - Serum total bilirubin ≤ 1.5 ULN or in subjects with biliary stenting ≤ 2 ULN; No prior treatment (chemotherapy, radiotherapy and/or surgery) for pancreatic cancer.

Exclusion: Concurrent treatment with other experimental drugs; Prior (within 1 year) or concurrent malignancies at other sites with the exception of surgically cured carcinoma in-situ of the cervix and basal or squamous cell carcinoma of the skin; Known infection with hepatitis B or C, or history of human immunodeficiency virus (HIV) infection, or subject receiving immunosuppressive or myelosuppressive medications that would in the opinion of the investigator, increase the risk of serious neutropenic complications; Serious medical risk factors involving any of the major organ systems, or serious psychiatric disorders, which could compromise the subject's safety or the study data integrity. These include, but are not limited to: a. History of connective tissue disorders (eg, lupus, scleroderma, arteritis nodosa) b. History of interstitial lung disease, slowly progressive dyspnea and unproductive cough, sarcoidosis, silicosis, idiopathic pulmonary fibrosis, pulmonary hypersensitivity pneumonitis or multiple allergies c. History of the following within 6 months prior to Cycle 1 Day 1: a myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft, New York Heart Association (NYHA) Class III-IV heart failure, uncontrolled hypertension, clinically significant cardiac dysrhythmia or ECG abnormality, cerebrovascular accident, transient ischemic attack, or seizure disorder; Other types of non-ductal tumor of the pancreas, including endocrine tumors or acinar cell adenocarcinoma, cystadenocarcinoma and other periampullary malignancies; Any condition that confounds the ability to interpret data from the study; Any familiar, sociologic or geographic conditions that can potentially interfere with the adhesion to the protocol or to the follow-up; Inflammatory disease of the colon or rectum, or occlusion or sub-occlusion of the intestine; Active, uncontrolled bacterial, viral, or fungal infection(s) requiring systemic therapy, defined as ongoing signs/symptoms related to the infection without improvement despite appropriate antibiotics, antiviral therapy, and/or other treatment; Clinical stage IV (including ascites or malignant pleural effusion) disease according to TNM 8th Ed. 2017 [appendix 1]; Locally advanced disease according to NCCN Guidelines Version 1.2020 – Pancreatic Adenocarcinoma [appendix 2]; Any condition including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study; Any significant medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from participating in the study; Pre-existing neuropathy; c.1679GG, c.1905+1AA, c.2846TT mutations in homozygous in DPYD gene. Dose modification according to DPYD and UGT1A1 mutations are reported in Table 1 (https://www.aiom.it/wp-content/uploads/2019/10/2019_Racc-analisi-farmacogenetiche.pdf.); Fructose intolerance; Symptomatic duodenal stenosis.

EU CTIS 2024-519031-42-00