BEAT Fatigue
Key facts
- Where
- Esbjerg, Odense C és Slagelse, DániaSee the 3 sites
- Phase
- 4. fázis
Where in Dánia
- Esbjerg Og Grindsted SygehusEsbjerg, DániaToborzás még nem indult
- Odense University HospitalOdense C, DániaToborzás még nem indult
- Slagelse HospitalSlagelse, DániaToborzás még nem indult
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Odense University Hospital
- Trial code
- EU 2024-519268-41-00
- Record updated
- 2026. június 12.
- Original description
The primary objective is to compare the effect of High Dose Tiamine (HDT,) relative to placebo, on the change from baseline to 4 weeks in the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional-Questionnaire global (BRAF-MDQ-global) (16), among patients diagnosed with RA suffering from fatigue.Read full original descriptionShow less
BEAT Fatigue – Benefit of Elevated Administration of Thiamine for Fatigue in Rheumatoid Arthritis: A randomized, double-blind, placebo-controlled trial
The primary objective is to compare the effect of High Dose Tiamine (HDT,) relative to placebo, on the change from baseline to 4 weeks in the Bristol Rheumatoid Arthritis Fatigue Multi-Dimensional-Questionnaire global (BRAF-MDQ-global) (16), among patients diagnosed with RA suffering from fatigue.
Inclusion: Patients with an established diagnose of rheumatoid arthritis; > 18 years of age; Able to read and understand Danish and give informed consent; Score of > 50 mm on a 100 mm visual analogue fatigue scale; Willingness to ensure effective contraception during the study period.
Exclusion: Patients treated with doses of prednisone exceeding 10 mg/day; Patients who by virtue of illiteracy or cognitive impairment are unable to complete the questionnaires; Known allergic reaction to Thiaminhydrochlorid; Co-morbidity that can explain high levels of fatigue including cancer, chronic kidney disease, chronic heart failure, diabetes; Modification of treatment of the inflammatory rheumatic disease within 3 months; Iron deficiency (Ferritin < 15 µg/L); TSH abnormalities; Folate acid deficiency (< 9 nmol/L); Vitamin B12 deficiency (cobalamin < 200 ρmol/L); Vitamin D deficiency (< 50 nmol/L); Pregnant women.