A randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
Key facts
- Where
- Goteborg, Orebro és Stockholm, SvédországSee the 3 sites
- Phase
- 4. fázis
Where in Svédország
- Sahlgrenska University Hospital-Vaestra GoetalandsregionenGoteborg, SvédországToborzás még nem indult
- Region Oerebro LaenOrebro, SvédországToborzás még nem indult
- Region Stockholm – SLSOStockholm, SvédországToborzás még nem indult
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Karolinska Institutet
- Trial code
- EU 2024-519407-99-00
- Record updated
- 2026. július 15.
- Original description
The main objective of this trial is to to test if the reduction of depressive symptoms after six electroconvulsive therapy (ECT) sessions is larger in patients anesthetized with a low thiopental dose compared to patients anesthetized with a high thiopental dose during ECT.Read full original descriptionShow less
Thiopental Induction Dose during Electroconvulsive therapy for depression (TIDE) - a randomized controlled trial of the effect of anesthetic dose during electroconvulsive therapy for major depression
The main objective of this trial is to to test if the reduction of depressive symptoms after six electroconvulsive therapy (ECT) sessions is larger in patients anesthetized with a low thiopental dose compared to patients anesthetized with a high thiopental dose during ECT.
Inclusion: age 18 years and above • hospitalized patients with an ongoing major depressive episode within MDD.
Exclusion: postpartum depression • schizophrenia • psychotic syndrome • bipolar disorder • patients for whom the anesthesiologist deems that a high anesthetic dose is inappropriate due to a somatic condition. • patients under compulsory psychiatric care according to the Swedish Act on Compulsory Psychiatric Care (Lagen om psykiatrisk tvångsvård) • patients who do not speak or understand Swedish or English sufficiently to provide informed consent or complete study assessments.