Psilocybin versus Personalized Neuromodulation for Resistant Depression (PSILO-MODULATION)
Key facts
- Where
- Chieti Scalo, Colleferro (RM) és Foggia, OlaszországSee the 3 sites
- Phase
- 2. fázis
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 64 years old?
Where in Olaszország
- Universita' Degli Studi G. D'Annunzio Di ChietiChieti Scalo, OlaszországTaking people
- ASL Roma 5Colleferro (RM), OlaszországTaking people
- Azienda Ospedaliero Universitaria - Policlinico Riuniti FoggiaFoggia, OlaszországTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universita' Degli Studi G. D'Annunzio Di Chieti
- Trial code
- EU 2024-519844-34-03
- Record updated
- 2025. november 19.
- Original description
Compare the effectiveness of psilocybin and personalized rTMS in Treatment Resistant Depression (TRD)Read full original descriptionShow less
Advancing PRecise Interventions for resistant DEpression: rebalancing brain networks and investigating the trajectories of antidepressant effect with psilocybin and personalized neuromodulation (PRIDE)
Compare the effectiveness of psilocybin and personalized rTMS in Treatment Resistant Depression (TRD)
Inclusion: Age between 18 and 65 years; Diagnosis of TRD: subjects with a MDD diagnosis, non-responders to at least two antidepressant medications at adequate doses administered for adequate time (i.e., 4-6 weeks).
Exclusion: Previous episodes of seizures; Substance use disorders; Psychotic disorders; Presence of severe organic/neurological comorbidities; Cognitive decline; Pregnancy/postpartum state.