A randomised, double-blind, comparative clinical trial of the effectiveness and tolerability of fentanyl in continuous parenteral perfusion versus on-demand bolus of morphine for the treatment of refractory dyspnoea in patients hospitalised for acute dec
Key facts
- Where
- Terrassa, SpanyolországSee the site
- Phase
- 4. fázis
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 64 years old?
Where in Spanyolország
- Fundacio Assistencial De Mutua De Terrassa FpcTerrassa, SpanyolországToborzás még nem indult
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundacio Assistencial De Mutua De Terrassa Fpc
- Trial code
- EU 2024-520025-36-00
- Record updated
- 2025. január 27.
- Original description
To evaluate the effectiveness and tolerability of fentanyl in PCSC, compared with the administration of morphine in BSC on demand, for the treatment of refractory dyspnea in patients hospitalized for acute decompensation of HF.Read full original descriptionShow less
To evaluate the effectiveness and tolerability of fentanyl in PCSC, compared with the administration of morphine in BSC on demand, for the treatment of refractory dyspnea in patients hospitalized for acute decompensation of HF.
Inclusion: Age equal to or greater than 18 years. 2. Hospitalized at the Mútua Terrassa University Hospital in the internal medicine units and complex chronic patient unit, due to HF decompensation, of any etiology. Patients may be included only once during each hospital admission; In case of re-entry for the same reason, they may be included again. 3. In optimized treatment of their HF decompensation at the discretion of the specialist doctor responsible for the case. 4. Refractory dyspnea persists despite treatment. 5. Has received two or more doses of 3 mg of SC morphine on demand for dyspnea in the previous 24 hours, as indicated by the responsible physician. 6. The patient gives informed consent that attests to his or her correct understanding of the purposes and procedures of the study and his desire to voluntarily participate in the study. In the event that the patient, due to his or her personal conditions or clinical situation, cannot grant consent, it will be the family member or primary caregiver who receives the explanations and grants consent. 7. It is expected that the patient will be able to complete questionnaires on the effectiveness and tolerability of the drugs administered. Otherwise, it is expected that the family member or the main reference caregiver will be able to complete these questionnaires.
Exclusion: History of alcohol or drug abuse. 2. Allergy to fentanyl or morphine 3. Contraindication to opioid use: Known hypersensitivity to morphine. Patients with respiratory depression or severe obstructive respiratory disease. Patients with acute bronchial asthma. Patients treated with monoamine oxidase inhibitors or during the 14 days following the suspension of such treatment. Patients with acute and/or severe liver disease. Patients with head injury; increased intracranial pressure. Patients in coma. Patients with spasms of the renal and biliary tract. Patients with acute alcoholism. Patients at risk of paralytic ileus. Patients with ulcerative colitis. Patients in shock. In case of infection at the injection site and in patients with severe coagulation disorders, epidural or intrathecal administration is contraindicated. 4. Concomitant treatment with opioids for other causes. 5. Simultaneous participation in another study or clinical trial.