Pharmacokinetics and pharmacodynamics of amiodarone in critically ill patients treated for atrial fibrillation - a randomised clin
Key facts
- Where
- Aalborg, DániaSee the site
- Phase
- 4. fázis
Where in Dánia
- Aalborg University HospitalAalborg, DániaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Aalborg University Hospital
- Trial code
- EU 2025-521289-88-02
- Record updated
- 2026. május 28.
- Original description
To examine pharmacokinetics of amiodarone by measuring concentrations of amiodarone and its active metabolite N-desethylamiodarone in blood, in bronchoalveolar lavage and in exhaled breath condensate during intravenous amiodarone (standard of care) versus interal amiodarone (intervention) in critically ill mechanically ventilated patients with new-onset atrial fibrillation.Read full original descriptionShow less
Pharmacokinetics and pharmacodynamics of intravenous versus enteral amiodarone in critically ill patients with new-onset atrial fibrillation – a randomised controlled pilot trial
To examine pharmacokinetics of amiodarone by measuring concentrations of amiodarone and its active metabolite N-desethylamiodarone in blood, in bronchoalveolar lavage and in exhaled breath condensate during intravenous amiodarone (standard of care) versus interal amiodarone (intervention) in critically ill mechanically ventilated patients with new-onset atrial fibrillation.
Inclusion: Adults (18 years of age or older); Admitted to the intensive care unit; Treated with a single dose of intravenous amiodarone 150-300 mg for new-onset atrial fibrillation; Needing continuous treatment with amiodarone for new-onset atrial fibrillation; Invasively mechanically ventilated; Normal gastrointestinal function defined as uncomplicated enteral feeding with aspirate less than 300 mL per day.
Exclusion: Persistent or paroxysmal atrial fibrillation treated with amiodarone prior to hospitalisation; Treated with amiodarone during the current hospitalisation prior to intensive care unit admission; Known allergy to amiodarone; Pregnancy; Under coercive measures.