Post-INFECT: Investigating Neuroinflammation and its effects in post-COVID syndrome
Key facts
- Where
- Amsterdam, HollandiaSee the site
- Phase
- 3. fázis
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 64 years old?
Where in Hollandia
- Amsterdam UMC StichtingAmsterdam, HollandiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Amsterdam UMC Stichting
- Trial code
- EU 2025-522349-23-00
- Record updated
- 2026. június 1.
- Original description
To assess differences between participants with persistent post-COVID complaints and controls without persistent post-COVID complaints in cellular metabolism in the brain as measured with dynamic [18F]FDG PET, structural and functional brain parameters as assessed with MRI, and immune-related blood parameters.Read full original descriptionShow less
Post-INFECT: Investigating Neuroinflammation and its eFEcts in post-COVID syndrome: an imaging sTudy
To assess differences between participants with persistent post-COVID complaints and controls without persistent post-COVID complaints in cellular metabolism in the brain as measured with dynamic [18F]FDG PET, structural and functional brain parameters as assessed with MRI, and immune-related blood parameters.
Inclusion: The subject was diagnosed with mild symptomatic COVID-19, confirmed by a positive PCR for SARS- CoV-2, positive SARS-CoV-2 serology or CO-RADS (COVID-19 Reporting and Data System) 4 or 5 on CT-scan, or antigen quicktest, or had typical symptoms and was part of a household in which another person was tested positive by PCR 2 weeks before or after the first day of illness; The subject is at least one year after being diagnosed with COVID-19; Subjects with persistent post-COVID complaints experience severe levels of fatigue (≥ 35) on the fatigue subscale of the Checklist Individual Strength [CIS-fatigue]) and/or difficulty concentrating (≥18) on the concentration subscale of the Checklist Individual Strength [CIS-concentration]. Control subjects without persistent complaints experiences no fatigue (<35) on the CIS-fatigue and no difficulty concentrating (<18) on the CIS-concentration; The subject is in the range 30-65 years of age; The subject has sufficient command of the Dutch language.
Exclusion: The subject is actively using anti-inflammatory drugs; The subject has an already known psychiatric, somatic or neurodegenerative condition that can explain his/her complaints; The subject is unable to lay still for scanning due to claustrophobia, severe back pain or trypanophobia (fear of needles); The subject is of female sex with childbearing potential and not surgically sterile, not refraining from sexual activity or not using reliable methods of contraception. Females of childbearing potential must orally and in writing confirm not to be pregnant or breastfeeding at the time of screening and at the day of the PET scan.