SAVE trial
Key facts
- Where
- Barcelona, Donostia, Girona, Palma, Santander és Zaragoza, SpanyolországSee the 7 sites
- Phase
- 3. fázis
Where in Spanyolország
- Hospital de la Santa Creu i Sant PauBarcelona, SpanyolországToborzás még nem indult
- Hospital del MarBarcelona, SpanyolországToborzás még nem indult
- Hospital Universitario DonostiaDonostia, SpanyolországToborzás még nem indult
- Hospital Universitari de Girona Doctor Josep TruetaGirona, SpanyolországToborzás még nem indult
- University Hospital Son EspasesPalma, SpanyolországToborzás még nem indult
- Hospital Universitario Marqués de ValdecillaSantander, SpanyolországToborzás még nem indult
- Hospital Universitario Miguel ServetZaragoza, SpanyolországToborzás még nem indult
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fundacio Institut De Recerca De L'Hospital De La Santa Creu I Sant Pau
- Trial code
- EU 2025-523709-13-00
- Record updated
- 2026. április 7.
- Original description
Compare the final volume of cerebral infarction by magnetic resonance imaging at 72 hours in patients with acute ischemic stroke undergoing mechanical thrombectomy under general anesthesia, who are randomly assigned to receive anesthetic maintenance with sevoflurane or propofol.Read full original descriptionShow less
Sevoflurane vs. propofol for general Anesthesia in patients with acute ischemic stroke treated with endoVascular treatmEnt (SAVE trial)
Compare the final volume of cerebral infarction by magnetic resonance imaging at 72 hours in patients with acute ischemic stroke undergoing mechanical thrombectomy under general anesthesia, who are randomly assigned to receive anesthetic maintenance with sevoflurane or propofol.
Inclusion: Age >18 years; Acute ischemic stroke within 24 hours from the last time seen well (LTSW), undergoing emergency endovascular treatment (EVT), with or without prior thrombolysis; Intracranial occlusion in the anterior circulation, including occlusions in segments M1 and M2 of the middle cerebral artery and/or the terminal portion of the internal carotid artery (TICA). Tandem lesions affecting extracranial segments of the internal carotid artery will also be included; Alberta Stroke Program Early CT Score (ASPECTS) ≥6 on baseline computed tomography (CT); Pre-stroke modified Rankin Scale (mRS) score of 0–3; Indication for general anesthesia at the start of the procedure (<30 minutes from femoral puncture) due to one of the following reasons: • Confusion or lack of patient cooperation. • Technical difficulties, such as complex arterial access, vascular tortuosity, need for extra- or intracranial stent placement, distal/medium vessel occlusions, among others. • Treating team's preference; Ability of the patient or the family member/legal representative to provide informed consent.
Exclusion: History of a previous severe adverse reaction to halogenated anesthetics, including hepatotoxicity associated with their use; Acute respiratory failure requiring orotracheal intubation; Known hypersensitivity to propofol, sevoflurane, or any of their excipients; Personal or family history of malignant hyperthermia, or suspected susceptibility to malignant hyperthermia (contraindication to halogenated anesthetics such as sevoflurane); Presence of hemorrhagic lesions on baseline CT; Occlusions in the anterior cerebral artery (ACA); Occlusions in the posterior circulation, including vertebral, basilar, or posterior cerebral arteries (PCA); Hemodynamic instability; Decision to perform general anesthesia due to complications during the endovascular treatment.