Impact of Early Thyroid Hormone Replacement on Kidney Function and Health-Related Quality of Life in Patients at Risk of Postoperative Hypothyroidism after Hemithyroidectomy: A Randomised Controlled Trial
Key facts
- Where
- Aarhus N és Herning, DániaSee the 2 sites
- Phase
- 4. fázis
Where in Dánia
- Region MidtjyllandAarhus N, DániaTaking people
- Region MidtjyllandHerning, DániaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Region Midtjylland
- Trial code
- EU 2025-524175-23-00
- Record updated
- 2026. március 3.
- Original description
To evaluate whether postoperative treatment with LT4 leads to an improvement in kidney function - measured as change in eGFR - three months after HT, compared to standard care without LT4Read full original descriptionShow less
To evaluate whether postoperative treatment with LT4 leads to an improvement in kidney function - measured as change in eGFR - three months after HT, compared to standard care without LT4
Inclusion: Patients referred for a first hemithyroidectomy; TSH ≥2 mUI/L; eGFR > 30 mL/min/1.73m2; Age 18 years or above; Ability to understand the study information and provide written informed consent; Able and willing to comply with study procedures and attend scheduled visits.
Exclusion: Previous thyroid operation; Initiated treatment with either ACE inhibitors, ARB or SGLT2 after surgery; Treatment with Thycapzole or similar medication with direct effect on thyroid hormones; Concomitant operation for primary hyperparathyroidism (PHPT); Cancer treatment within the last three years; Severe cardio-vascular disease (atrial fibrillation, heart failure etc.); Severe other illness (psychiatric disorder, kidney disease with GFR < 30 etc.); Inability to understand Danish or provide informed consent; Participation in another interventional study that may interfere with outcomes; Planned total thyroidectomy or completion thyroidectomy during follow-up; Pregnancy or plans of pregnancy in the postoperative period; Use of narcotics or alcohol abuse.