Not yet taking people in Csehország2. fázis
Prevention of radiation-induced salivary gland damage by botulinum toxin application in patients with head and neck cancers
Key facts
- Where
- Prague, CsehországSee the site
- Phase
- 2. fázis
Where in Csehország
- Fakultni nemocnice Kralovske VinohradyPrague, CsehországToborzás még nem indult
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fakultni Nemocnice Kralovske Vinohrady
- Trial code
- EU 2025-524720-22-00
- Record updated
- 2026. június 2.
- Original description
To evaluate whether intraglandular application of botulinum toxin type A prior to radiotherapy preserves salivary gland function.Read full original descriptionShow less
To evaluate whether intraglandular application of botulinum toxin type A prior to radiotherapy preserves salivary gland function.
Inclusion: Age ≥ 18 years; Histologically confirmed head and neck squamous cell carcinoma indicated for radiotherapy; Symmetrical function of submandibular glands on pre-treatment Tc99m scintigraphy; Signed informed consent.
Exclusion: Previous radiotherapy to the head and neck region; Prior surgery affecting major salivary glands (to be evaluated individually); Known salivary gland disease (e.g., sialolithiasis, recurrent sialadenitis); Known allergy to botulinum toxin or neuromuscular transmission disorders; Pregnancy or lactation.