Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Hodgkin's Lymphoma

A regiszterben nem jelölt feltételek

• DISEASE CHARACTERISTICS:
• Randomized groups: Histologically proven previously untreated stage I or II supradiaphragmatic Hodgkin's lymphoma
  • No prior staging laparotomy
  • Favorable (closed to accrual as of 4/28/04) or unfavorable (closed to accrual as of 9/2002) prognosis
• Nonrandomized group: Histologically proven lymphocyte-predominant Hodgkin's lymphoma, nodular subtype (nodular paragranuloma)
  • Stage I with complete or incomplete resection OR
  • Stage II
  • PATIENT CHARACTERISTICS:
  • Age:
• 15 to 70
  • Performance status:
• WHO 0-2
  • Life expectancy:
• Not specified
  • Hematopoietic:
• Not specified
  • Hepatic:
• Not specified
  • Renal:
• Not specified
  • Cardiovascular:
• No severe cardiac disease that would interfere with normal life expectancy or study treatment
  • Pulmonary:
• No severe pulmonary disease that would interfere with normal life expectancy or study treatment
  • Other:
• No other prior or concurrent malignancy except basal cell skin cancer or carcinoma in situ of the cervix
• No severe neurologic or metabolic disease that would interfere with normal life expectancy or study treatment
• No psychologic, familial, socioeconomic, or geographic circumstances that would preclude proper staging or compliance
• HIV negative
• Not pregnant
• Fertile patients must use effective contraception
  • PRIOR CONCURRENT THERAPY:
  • Biologic therapy
• No prior biologic therapy for this malignancy
  • Chemotherapy
• No prior chemotherapy for this malignancy
  • Endocrine therapy
• No prior endocrine therapy for this malignancy
  • Radiotherapy
• No prior radiotherapy for this malignancy
  • Surgery
• No prior surgery for this malignancy