Cellular Aging and Neurobiology of Depression Study

A regiszterben nem jelölt feltételek

• All participants must meet the following criteria:
• Age 21-60 and able to give informed consent.
• Not "needle phobic," by self-report.
• English-speaking (to allow accurate use of behavioral rating scales and verbal cognitive tests).
• Females of child-bearing capacity must be non-pregnant (confirmed by urine pregnancy test) and using effective non-hormonal birth control (e.g. abstinence, condoms, IUD).
• Good general medical health; no significant uncontrolled illnesses that will invalidate the designated outcome measures.
• Clinical labs (electrolytes, liver function test, CBC) with no clinically significant abnormalities that result in medical treatment that will invalidate the designated outcome measures.
• Negative urine toxicology (drugs of abuse) screen.
• Taking no medication or drugs likely to interfere with the study objectives (including statins or medications that affect hormones [e.g. birth control pills or steroids]).
• Free of all psychotropic medications (including antidepressants) for at least 6 weeks (with the exception of prn short-acting benzodiazepines or sedative-hypnotics, < 3 doses per week, and none for 5 drug half-lives before the study).
• No vaccines for at least 4 weeks prior to baseline blood draw (including the flu shot).
• Not currently anemic (Hct of 36-48 for females and 38-54 for males, or Hgb of 12.5-20) and has not donated blood for at least 8 weeks prior to baseline blood draw.
• No neurological disorders and no history of concussion with a black-out that lasted > 10 minutes.
• Willing to provide stool sample
  • Additional criteria for Depressed Participants:
• Current DSM-5 diagnosis of Major Depressive Disorder, unipolar, with non-psychotic features.
• Baseline 17-item Hamilton Depression Rating Scale (HDRS) rating of >= 17, or Baseline 25-item HDRS rating of >= 20.
• Current depressive episode duration of > 6 weeks.
• No current, active suicidal intent; HDRS "suicidality" item rating <= 2 OR by clinician determination.
• No recent (< 6 month) history of substance or alcohol use disorder(s), with the exception of tobacco use (DSM-5 criteria).
• No current (in the last month) diagnosis of Post-Traumatic Stress Disorder (DSM-5 criteria).
• No anticipated changes in psychotherapeutic interventions during the course of the study.
  • Additional criteria for Normal Controls:
• No history of DSM-5 Axis I diagnoses