Combined Rituximab and Lenalidomide Treatment for Untreated Patients With Follicular Lymphoma

Korábbi kezelés

• Major surgery (excluding lymph node biopsy) within 28 days prior to signing informed consent.

Más betegség

• Known seropositive for or active viral infection with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV)
• Known sensitivity or allergy to murine products.
• Presence or history of central nervous system involvement by lymphoma

Laborértékek

• Any of the following laboratory abnormalities:
• serum aspartate transaminase or alanine transaminase > 3x upper limit of normal (ULN), except in patients with documented liver involvement by lymphoma
• total bilirubin > 2.0 mg/dl (34 µmol/L) except in cases of Gilberts Syndrome and documented liver or pancreatic involvement by lymphoma
• creatinine clearance of < 30 mL/min

Egyéb

• Clinical evidence of transformed lymphoma or Grade 3b follicular lymphoma.
• At high risk for a venous thromboembolic event (VTE) and not willing to take VTE prophylaxis

• Histologically confirmed follicular lymphoma grade 1, 2 or 3a, Stage II-IV
• Have no prior systemic treatment for lymphoma
• Symptomatic follicular lymphoma requiring treatment.
• Age ≥18 years
• Eastern Cooperative oncology group performance status 0-2
• Willing to follow pregnancy precautions