Hypofractionated Stereotactic Body Radiation Therapy as a Boost to the Prostate

Korábbi kezelés

• No prior prostate surgery (including TURP) or prostate cancer treatment with the exception of androgen deprivation therapy
• No prior radiotherapy to the pelvis

Más betegség

• No metastatic disease, with the exception of lymph node positive disease
• No chemotherapy for a malignancy in the last 5 years.
• No history of an invasive malignancy (other than basal or squamous skin cancers) in the last 5 years.
• No heart pacemaker, No metallic foreign body (metal sliver) in the eye, No aneurysm clip in the brain
• No history of a pelvic or horseshoe kidney
• No diagnosis of inflammatory bowel disease

Egyéb

• No implanted hardware (including metal) or other material that would prohibit appropriate treatment planning or treatment delivery

• Histologically proven adenocarcinoma of the prostate
  • Gleason score (2-10)
  • Biopsy within six months of date of registration
  • Patient age >18 years
• Clinical stage (American Joint Committee on Cancer 7th Edition)
  • T-stage determined by physical exam (Digital Rectal Exam Required)
  • MRI findings (e.g. extracapsular extension) can be used to determine T-staging
  • N-stage determined using abdominopelvic CT scan and/or MRI
  • M-stage determined by physical exam, CT and/or MRI, and bone scan (must be M0, excepting Lymph nodes)
  • Please note: a SPECT bone scan including a CT of the abdomen and pelvis or an F18 Fluciclovine PET/CT fulfills protocol criteria for both the abdominopelvic CT and bone scan.
• Patients must belong to one of the following risk groups:
  • PSA > 20 and < 150 and/or
  • Gleason 8-10 and/or
  • > clinical T3a and/or
  • Clinical N1
  • OR
  • PSA 10 - 20 AND
  • Gleason 7 AND
  • Clinical T2b - T2c
• Patient is receiving, or planning to receive standard androgen deprivation therapy and initial IMRT to the prostate and positive or at-risk lymph nodes.
• Prostate volume greater than 20 cc and less than 100 cc
• Eastern Cooperative Oncology Group (ECOG) performance status 0-1
• Patient has agreed to complete questionnaires
• Signed IRB approved informed consent
• Patient eligible to have an MRI
• Must be able to tolerate the confinement of an MRI procedure