Functional and Structural Imaging for Glaucoma

Korábbi kezelés

• Previous intraocular surgery except for uncomplicated keratorefractive surgery and cataract extraction with posterior chamber intraocular lens implantation

Más betegség

• Other diseases that may cause VF loss or optic disc abnormalities
• Life-threatening or debilitating illness making it unlikely patient could successfully complete the study.

Életkor

• Age < 40 or >85 years

Egyéb

• Best-corrected visual acuity less than 20/40
• Refractive error of > +3.00 D or < -7.00 D
• Diabetic retinopathy
• Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil
• Inability to perform reliably on automated VF testing
• Refusal of informed consent or of commitment to the full length of the study

• No history or evidence of retinal pathology or glaucoma
• Normal Humphrey 24-2 VF: A mean defect (MD), corrected pattern standard deviation (CPSD) within 95% limits of normal reference, and glaucoma hemifield test (GHT) within normal limits (97%).
• Intraocular pressure < 21 mm Hg
• Central corneal pachymetry > 500 microns
• No chronic ocular or systemic corticosteroid use
• Open angle (gonioscopy must show 75% or more of the angle to be Grade 2 or more by Shaffer's grading system)
• Normal appearing ONH and NFL: vertical and horizontal cup/disc ratio (CDR) ≤ 0.5 and intact neuroretinal rim without peripapillary hemorrhages, notches, localized pallor, or NFL defect
• Symmetric ONH between left and right eyes: CDR difference < 0.2 in both vertical and horizontal dimensions
• ONH or NFL defect visible on slit-lamp biomicroscopy defined as one of following:
  • diffuse or localized thinning of the rim
  • disc (splinter) hemorrhage
  • notch in the rim
  • vertical cup/disc ratio greater than the fellow eye by > 0.2
• Presence or absence of VF defects as measured by Humphrey SITA 24-2 VF.