The CCP Study: Coordinated Programme to Prevent Arthritis - Can We Identify Arthritis at a Pre-clinical Stage ?

Más betegség

• Subjects with any of the following conditions or characteristics will be excluded

Laborértékek

• For the MRI imaging component, the following exclusions will apply; pacemaker, surgical clips within the head, certain inner ear implants, neuro-electrical stimulators or metal fragments within the eye or head or eGFR < 45 ml/min/1.73 m2. In patients with previous penetrating trauma to the eye, or patients at high risk of previous metal foreign body injury to the eye (e.g. welding), skull x-ray will be performed; these patients may be included in the absence of residual metal fragments on x-ray.
  • Rheumatology clinic referred patients:
  • Subjects with any of the following conditions or characteristics will be excluded
• For the MRI imaging component, the following exclusions will apply; pacemaker, surgical clips within the head, certain inner ear implants, neuro-electrical stimulators or metal fragments within the eye or head or eGFR < 45 ml/min/1.73 m2. In patients with previous penetrating trauma to the eye, or patients at high risk of previous metal foreign body injury to the eye (e.g. welding), skull x-ray will be performed; these patients may be included in the absence of residual metal fragments on x-ray.

Egyéb

• GP and Musculoskeletal referred patients:
• Patients with clinical synovitis
• Patient fulfils 1987 ACR Criteria or the 2010 ACR/EULAR criteria for RA
• Patient has tested CCP Ab negative
• Patient fulfils 1987ACR Criteria or the 2010 ACR/EULAR criteria for RA

• For the purpose of this study, "musculoskeletal complaint" is defined as any new joint / muscular symptoms, including (but not limited to)
• Rotator cuff tendonitis / subacromial bursitis
• Carpal tunnel syndrome
• Tendonitis e.g. epicondylitis "New" complaint is defined as a symptom in which the patient has not previously reported to their GP.
  • GP and Musculoskeletal referred patients:
  • Subject must fulfil all of the following conditions or characteristics in order to be considered for study enrolment or participation:
• Is age > 18 years
• Has a new musculoskeletal complaint or has a family member with RA
• Is capable of understanding and signing an informed consent form
  • Rheumatology Clinic referred patients:
  • Subject must fulfil all of the following conditions or characteristics in order to be considered for study enrolment or participation:
• Is age > 18 years
• Has a new musculoskeletal complaint
• Is capable of understanding and signing an informed consent form
• Has tested CCP Ab positive