Impact of Chemo-induced Menopause on Quality of Life in Women <45 Years Old, Diagnosed With Non-metastatic Breast Cancer

Korábbi kezelés

• Patient who underwent surgical castration of ovariectomy or hysterectomy or tubal ligation
• Patients who have had hormone therapy or chemotherapy
• Participation in another clinical trial involving the chemical or surgical castration of the patient

Más betegség

• Metastatic cancer
• Any T4 tumor (skin invasion, deep grip, inflammatory breast cancer)
• Presence of comorbidities related to fertility or medical history related to ovarian failure or sterility
• Significant neurological or psychiatric abnormalities

Egyéb

• Male patient
• Patients with endometriosis
• Pregnant or breastfeeding patients
• Patients with no effective contraception
• Patient who have already taken Gn-RH or LH-RH analogues (chemical castration)
• Patient whose mother was in menopause early without treatment
• Inability of the patient to complete the questionnaires (the language barrier)
• Patients deprived of liberty by court or administrative decision
• Patient with another pathology deemed incompatible with the inclusion of the patient in the protocol
• Patients geographically unstable in the 6 months following inclusion or residing away from the treatment center and thereby making it difficult to monitor

• Patient aged over 18 and under 45
• Patient without amenorrhea at diagnosis
• Performance status less than 2 (according to WHO criteria )
• Patient diagnosed with histologically proven non-metastatic breast cancer
• Clinical Stages I, IIA, IIB and IIIA
• Positive Hormone Receptors (defined by a rate of 10% of labeled cells and immunohistochemistry (IHC) ) or negative
• Positive or negative HER2 status ( defined a score of 0 or 1 + by IHC , or a 2 + score by IHC and FISH / ISHS / CISH negative)
• Patients to be treated with neoadjuvant or adjuvant chemotherapy
• Satisfying hematological, renal and hepatic functions : PNN> 2,109 / L, platelets > 100 . 109 / L, Hb> 10 g / dl , normal bilirubin, AST and ALT <2.5 upper normal value ( VNS) , alkaline phosphatase <2.5 VSN , creatinine clearance > 60 ml / min
• Obtaining informed consent in writing, signed and dated
• Affiliation to Social Security system (or being the beneficiary of such a plan) under the terms of the Act of August 9, 2004