Cohort Analysis of Clinical and Biological Severe Childhood Asthma

Más betegség

• Child with severe sequelae of viral infections

Laborértékek

• Refusal of the child or parents Data collection for research and follow up of patients : tests carried out in the 3 months prior to inclusion are used
  • Blood sample for DNA extraction and the biobank: for young children, sampling at least 4 to 5 ml on dry tubes for serum and 6 ml at least for DNA. These samples should be stored at room temperature, transported within 48 hours to biological resources (CRB) Necker E,fa,ts Malades.

Egyéb

• Child with bronchopulmonary dysplasia

• Children with severe asthma:
• Child aged 3 to 12 years
• Asthmatic child who, despite treatment with a combination of inhaled corticosteroids (at least 800 mcg / day equivalent Beclomethasone) bronchodilators and long-acting or properly taken daily leukotriene or short acting nebulized bronchodilators (inhaler technique and compliance verified) presents one of the criteria following:
• Persistence of symptoms or chronic use of bronchodilators short duration of action at least three times a week for at least 3 months
• exacerbations in the previous year:
  • at least one care unit admission or continued resuscitation
  • at least two hospitalizations for acute severe asthma requiring IV therapy
  • at least 2 courses of oral corticosteroids for exacerbations
• post BD FEV <80% or UARS post BD> 150% predicted
• Signature of consent or the holder (s) of parental authority
• Particular case of patients treated with Xolair® : Patients currently receiving Xolair® but who met the severity criteria of asthma, as described above, before the start of treatment with Xolair® are includable.
  • Children with non-severe asthma:
• Child aged 3 to 12 years
• Controlled without treatment or with low doses of inhaled corticosteroids (<500 mg / day beclometasone equivalent) asthma
• Child with normal EFR (Child over 4 years)
• Child who did not have more severe exacerbation (assessed taking oral corticosteroids) in the previous year
• Child not admitted in the previous year for asthma.
• Signature of consent or the holder (s) of parental authority