Accuracy of an Echo-Stress Protocol Using Regadenoson With Speckle Tracking

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• Patients with allergy to regadenoson.

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• Patients consented for the trial that on the baseline 2D study have poor acoustic echo windows (i.e. a reader is unable to see in definition 2 or more segments from the apical views) will not be eligible to continue in the trial and peak hyperemia images will not be obtained.
• Any patient with tachycardia defined as HR of 100 or higher at the day of SPECT will not be eligible for this study.
• Second- or third- degree AV block.
• Sinus node dysfunction.
• Patients with LBBB and/or artificial pacemaker.

• Cancer patients who are scheduled for (perfusion) nuclear stress testing using regadenoson as stress agent.
• Indications for stress testing is either: -as part of a pre-operative evaluation prior to a planned cancer related surgery that is considered to be at least of intermediate risk (Intra-peritoneal, intra-thoracic, head and neck surgery, orthopedic or prostate surgery) OR -as an evaluation in the cardiology clinic for symptoms described in a cardiology consult as typical angina, or of significant suspicion for coronary disease or symptoms described as likely of a cardiac/coronary etiology.
• Patients with a history of LV dysfunction will be still candidates for enrollment in the study if they have documented LVEF recovery (most recent documented LVEF of 50% or higher) for at least 6 months prior to SPECT regardless of current cardiac medication regimen.
• Age 18 - 80 years.