Blood Pressure Reduction to Limit the Evolution of Vascular Brain Lesions in Elderly Individuals

Korábbi kezelés

• Patient already receiving 4 or more antihypertensive drugs at maximum dosage
• Patient participating in another clinical research study on drug requiring exclusion period

Más betegség

• Contraindication to MRI (presence of ferromagnetic foreign body (especially some intracranial clips, some heart valves, intraocular foreign bodies, metal prosthesis), subject carrying pacemaker, claustrophobic participants)
• Severe diseases associated with a life expectancy of less than 3 months;
• Presence of another dementia different than Alzheimer's disease vascular dementia or mixed dementia,
• Secondary hypertension: renovascular hypertension, primary aldosteronism, pheochromocytoma ...;
• severe renal impairment

Egyéb

• Presence of severe orthostatic hypotension defined as a decrease of 30 mmHg in SBP standing within 3 minutes
• Major physical impairments that can interfere with the feasibility of the tests (sight, hearing ...)
• Persons under guardianship;

• 60 to 88 years old patients;
• Patient with cognitive complaint with MMSE ≥ 20performed within 6 months prior to enrollment (with or without dementia)
• Patient with a socio-educational level ≥ 3
• Presence of hyperintensities of moderate to high grade on the last MRI or old scan (grades C and D on the modified Scheltens scale, grades 2/3 Fazekas).
• Hypertension defined by a Systolic Blood Pressure (SBP) and / or a Diastolic Blood Pressure (DBP) ≥ 140/90 mmHg, treated or not
• Affiliation to a social security system
• Informed consent given, signed consent